Evidence map›Paper›PMID 21113182›Full record

ReviewNature reviews. Microbiology2011

Microbiota restoration: natural and supplemented recovery of human microbial communities.

Gregor Reid, Jessica A Younes, Henny C Van der Mei, Gregory B Gloor, Rob Knight, Henk J Busscher

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2018
    Pooled it
  5. Nutrients · 2025
    Trial
  6. Trial
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  10. Article
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  12. Review
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  14. The Role ofBiomedicines · 2026
    Review
  15. Article
  16. Review
  17. The Neuroimmunology of Autism.Molecular neurobiology · 2025
    Review
  18. Article
  19. Article
  20. Article

183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gregor ReidHuman Microbiology and Probiotics, F2-116, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada. gregor@uwo.ca
Jessica A Younes
Henny C Van der Mei
Gregory B Gloor
Rob Knight
Henk J Busscher

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

In a healthy host, a balance exists between members of the microbiota, such that potential pathogenic and non-pathogenic organisms can be found in apparent harmony. During infection, this balance can become disturbed, leading to often dramatic changes in the composition of the microbiota. For most bacterial infections, nonspecific antibiotics are used, killing the non-pathogenic members of the microbiota as well as the pathogens and leading to a substantial delay in the restoration of a healthy microbiota. However, in some cases, infections can self-resolve without the intervention of antibiotics. In this Review, we explore the mechanisms underlying microbiota restoration following insult (antibiotic or otherwise) to the skin, oral cavity, and gastrointestinal and urogenital tracts, highlighting recovery by natural processes and after probiotic administration.

Indexed as

Bacterial Physiological PhenomenaSymbiosisBacteriaBacterial InfectionsDatabases, FactualHumansIntestinesProbioticsWounds and Injuries

Identifiers

PMID21113182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.