ArticleCell death and differentiation2011
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Article in Cell death and differentiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanisms of Protection Against Oxidative Stress During Hibernation.International journal of molecular sciences · 2026Review
- Highly expressed of BID indicates poor prognosis and mediates different tumor microenvironment characteristics in clear cell renal cell carcinoma.Discover oncology · 2024Article
- Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers.Science translational medicine · 2021Article
- Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.Cell death and differentiation · 2021Article
- A Gene Signature of Survival Prediction for Kidney Renal Cell Carcinoma by Multi-Omic Data Analysis.International journal of molecular sciences · 2019Article
- Article
- Non-apoptotic functions of BCL-2 family proteins.Cell death and differentiation · 2017Review
- Synergy of BID with doxorubicin in the killing of cancer cells.Oncology reports · 2015Article
- Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors.The Journal of biological chemistry · 2014Article
- Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis.BMC cancer · 2014Article
- Rejuvenating Bi(d)ology.Oncogene · 2013Review
- The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice.Cell death and differentiation · 2013Article
- Evolution of Bcl-2 homology motifs: homology versus homoplasy.Trends in cell biology · 2013Article
- Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.Cell death and differentiation · 2012Article
- Non-apoptotic functions of apoptosis-regulatory proteins.EMBO reports · 2012Review
- BID binds to replication protein A and stimulates ATR function following replicative stress.Molecular and cellular biology · 2011Article
- ATR signalling: more than meeting at the fork.The Biochemical journal · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proapoptotic BH3 interacting domain death agonist (Bid), a BH3-only Bcl-2 family member, is situated at the interface between the DNA damage response and apoptosis, with roles in death receptor-induced apoptosis as well as cell cycle checkpoints following DNA damage.(1, 2, 3) In this study, we demonstrate that Bid functions at the level of the sensor complex in the Atm and Rad3-related (Atr)-directed DNA damage response. Bid is found with replication protein A (RPA) in nuclear foci and associates with the Atr/Atr-interacting protein (Atrip)/RPA complex following replicative stress. Furthermore, Bid-deficient cells show an impaired response to replicative stress manifest by reduced accumulation of Atr and Atrip on chromatin and at DNA damage foci, reduced recovery of DNA synthesis following replicative stress, and decreased checkpoint kinase 1 activation and RPA phosphorylation. These results establish a direct role for the BH3-only Bcl-2 family member, Bid, acting at the level of the damage sensor complex to amplify the Atr-directed cellular response to replicative DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.