ArticleCell death and differentiation2011
Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1.
Article in Cell death and differentiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Apoptosis promotes fertility in Caenorhabditis elegans by maintaining functional germline morphology.Development (Cambridge, England) · 2026Article
- Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025Article
- The pattern of the follicle cell diversification in ovarian follicles of the true fruit flies, Tephritidae.Journal of anatomy · 2024Article
- JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development.Nature communications · 2024Article
- Activated Src kinase promotes cell cannibalism in Drosophila.The Journal of cell biology · 2023Article
- Distinct gene expression dynamics in germ line and somatic tissue during ovariole morphogenesis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2022Article
- E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway duringFrontiers in cell and developmental biology · 2022Article
- Review
- Cytokine exocytosis and JAK/STAT activation in theJournal of cell science · 2018Article
- JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis.Developmental biology · 2018Article
- Polar cell fate stimulatesDevelopment (Cambridge, England) · 2018Article
- Jak-Stat pathway induceseLife · 2018Article
- JAK/STAT signaling is necessary for cell monosis prior to epithelial cell apoptotic extrusion.Cell death & disease · 2017Article
- Article
- Diversity of cell death pathways: insight from the fly ovary.Trends in cell biology · 2013Review
- Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.Developmental biology · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although much has been learned in recent years about the apoptotic machinery, the mechanisms underlying survival and death choices during development of metazoans remain less clearly understood. During early oogenesis in Drosophila, a small excess in the number of specialized somatic cells, called polar cells (PCs), produced at follicle extremities is reduced to exactly two cells through apoptosis by mid-oogenesis. We have found that PCs destined to die first lose their apical contacts and then round up and shrink progressively until they disappear. Caspases are activated only once the cells have begun to shrink, suggesting that they are implicated in this part of the process, but not in the initial loss of cell polarity. Loss-of-function analyses based on mutant, clonal and RNAi approaches show that among the RHG family of pro-apoptotic factors, Hid is specifically necessary for PC apoptosis, as well as the initiator caspase Dronc and its adaptor Dark/Apaf-1, and likely several effector caspases, in particular Drice. In addition, we show that Hid protein and transcripts accumulate specifically in PCs destined to die, while the anti-apoptotic factor Diap1 is downregulated in these cells in a hid-dependent manner. Therefore, our results implicate the Hid-Diap1 module as an important regulatory point in a developmental case of apoptosis.
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