ArticleMolecular human reproduction2011
Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle.
Article in Molecular human reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 62 citations in OpenAlex.
- The Essential Role of PGF2α/PTGFR in Molding Endometrial Breakdown and Vascular Dynamics, Regulated by HIF-1α in a Mouse Menstrual-like Model.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Acquisition of Immune Privilege in GBM Tumors: Role of Prostaglandins and Bile Salts.International journal of molecular sciences · 2023Article
- Transcriptomic analysis of human endometrial stromal cells during early embryo invasion.Annals of medicine · 2021Article
- Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling.Animals : an open access journal from MDPI · 2021Article
- AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas.Journal of clinical medicine · 2020Article
- Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium.Human reproduction (Oxford, England) · 2019Article
- Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.International journal of molecular sciences · 2018Review
- Prostaglandin E2 receptor EP1 in healthy and diseased human endometrium.Histochemistry and cell biology · 2018Article
- Cyclooxygenase-2 inhibitor, celecoxib, inhibits leiomyoma cell proliferation through the nuclear factor κB pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Diverse roles of prostaglandins in blastocyst implantation.TheScientificWorldJournal · 2014Review
- Prokineticin 1 induces a pro-inflammatory response in murine fetal membranes but does not induce preterm delivery.Reproduction (Cambridge, England) · 2013Article
- Inflammation, leukocytes and menstruation.Reviews in endocrine & metabolic disorders · 2012Review
- Prostaglandin receptors EP and FP are regulated by estradiol and progesterone in the uterus of ovariectomized rats.Reproductive biology and endocrinology : RB&E · 2012Article
- The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions.Frontiers in pharmacology · 2012Article
- Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.Frontiers in pharmacology · 2012Article
- Induction of overt menstruation in intact mice.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prostanoids are well-described primary mediators of inflammatory processes and are essential for the normal physiological function of the female reproductive system. The aim of this study was to determine the temporal expression of the prostanoid biosynthetic enzymes (PTGS1, PTGS2, PTGES, PTGES2, PTGES3, AKR1B1, AKR1C3, CBR1, HPGDS, PTGDS, PTGIS, TBXAS1 and HPGD) and the prostanoid receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGDR, GPR44, PTGIR and TBXA2R) in the human endometrium throughout the menstrual cycle. The analysis identified PTGFR to have a distinct expression profile compared with other components of the prostanoid system, as expression is maximal during the proliferative phase. Immunohistochemical analysis for PTGER1 suggests a dual function for this receptor depending on its temporal (proliferative versus secretory) and spatial (nuclear versus cell membrane) expression. The expression profiles of the PGF(2α) synthases identified AKR1B1 and CBR1 as the likely regulators of PGF(2α) production during the menstrual phase. Immunohistochemical analysis for AKR1B1, CBR1 and AKR1C3 suggest expression to be in the glandular epithelium and vasculature. This study represents the first comprehensive analysis of the components of prostanoid biosynthetic and signalling pathway in the human endometrium. The expression profiles described have the potential to identify specific prostanoid components that may be dysregulated in inflammatory-associated disorders of the endometrium.
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Registered trials
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