ArticleMolecular biology and evolution2011
Testing spatiotemporal hypothesis of bacterial evolution using methicillin-resistant Staphylococcus aureus ST239 genome-wide data within a bayesian framework.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Testing the validity and adequacy of linguistic phylogenetic analyses.PLoS computational biology · 2026Article
- Dynamic Networks of Methicillin-ResistantOpen forum infectious diseases · 2025Article
- Epidemiological characterization of clinical isolates of meticillin resistant Staphylococcus aureus through multilocus sequence typing and staphylococcal cassette chromosome mec typing in Northwest Iran.Molecular biology reports · 2024Article
- StAP1 phage: an effective tool for treating methicillin-resistantFrontiers in microbiology · 2023Article
- Article
- Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China.Genome medicine · 2021Article
- Centre-specific bacterial pathogen typing affects infection-control decision making.Microbial genomics · 2021Article
- Article
- Characterization of 67 Confirmed Clustered Regularly Interspaced Short Palindromic Repeats Loci in 52 Strains ofFrontiers in microbiology · 2021Article
- Marginal Likelihoods in Phylogenetics: A Review of Methods and Applications.Systematic biology · 2019Review
- Unexpected Predictors of Antibiotic Resistance in Housekeeping Genes of Staphylococcus Aureus.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2019Article
- Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-ResistantAntimicrobial agents and chemotherapy · 2019Article
- Local Diversification of Methicillin- ResistantFrontiers in microbiology · 2019Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- The distribution of bacterial doubling times in the wild.Proceedings. Biological sciences · 2018Article
- The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.PLoS pathogens · 2018Observational
- Genomic Comparison of Highly Virulent, Moderately Virulent, and Avirulent Strains From a Genetically Closely-Related MRSA ST239 Sub-lineage Provides Insights Into Pathogenesis.Frontiers in microbiology · 2018Article
- Large-scale genomic analyses reveal the population structure and evolutionary trends of Streptococcus agalactiae strains in Brazilian fish farms.Scientific reports · 2017Article
- Genomic insights into the ancient spread of Lyme disease across North America.Nature ecology & evolution · 2017Article
- Genealogical Working Distributions for Bayesian Model Testing with Phylogenetic Uncertainty.Systematic biology · 2016Article
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7 authors.
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Abstract
Staphylococcus aureus is a common cause of infections that has undergone rapid global spread over recent decades. Formal phylogeographic methods have not yet been applied to the molecular epidemiology of bacterial pathogens because the limited genetic diversity of data sets based on individual genes usually results in poor phylogenetic resolution. Here, we investigated a whole-genome single nucleotide polymorphism (SNP) data set of health care-associated Methicillin-resistant S. aureus sequence type 239 (HA-MRSA ST239) strains, which we analyzed using Markov spatial models that incorporate geographical sampling distributions. The reconstructed timescale indicated a temporal origin of this strain shortly after the introduction of Methicillin, followed by global pandemic spread. The estimate of the temporal origin was robust to the molecular clock, coalescent prior, full/intergenic/synonymous SNP inclusion, and correction for excluded invariant site patterns. Finally, phylogeographic analyses statistically supported the role of human movement in the global dissemination of HA-MRSA ST239, although it was unable to conclusively resolve the location of the root. This study demonstrates that bacterial genomes can indeed contain sufficient evolutionary information to elucidate the temporal and spatial dynamics of transmission. Future applications of this approach to other bacterial strains may provide valuable epidemiological insights that may justify the cost of genome-wide typing.
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