Evidence map›Paper›PMID 21112495›Full record

ReviewGastrointestinal endoscopy clinics of North America2011

Biology of Barrett's esophagus and esophageal adenocarcinoma.

David H Wang, Rhonda F Souza

Abstract readReview
In one paragraph

Review in Gastrointestinal endoscopy clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. The Potential Role ofMicroorganisms · 2025
    Review
  2. Article
  3. Demystifying the Functional Role of Nuclear Receptors in Esophageal Cancer.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Molecules involved in the development of Barrett's esophagus phenotype in chronic eosinophilic esophagitis.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Circulating Tumor Cells in the Adenocarcinoma of the Esophagus.International journal of molecular sciences · 2016
    Review
  10. Review
  11. Review
  12. Article
  13. Expression of SOX9 and CDX2 in nongoblet columnar-lined esophagus predicts the detection of Barrett's esophagus during follow-up.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015
    Article
  14. Article
  15. Gastroesophageal reflux disease and non-esophageal cancer.World journal of gastroenterology · 2015
    Review
  16. Article
  17. Natural history of Barrett's esophagus.World journal of gastroenterology · 2012
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David H WangDepartment of Medicine, Veterans Affairs North Texas Health Care System, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Rhonda F Souza

Funding

Role of Acid in the Development of Barrett's EsophagusR01DK063621 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SOUZA, RHONDA F, SPECHLER, STUART JON · 2002 to 2015
$3.4M
Basic and Clinical Studies on the Role of Bile Acids in Barrett's EsophagusR01CA134571 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SOUZA, RHONDA F, SPECHLER, STUART JON · 2009 to 2013
$1.3M
Hedgehog in Barrett's esophagus & assoc. adenocarcinomaF32CA123945 · NCI · JOHNS HOPKINS UNIVERSITY · PI WANG, DAVID H · 2006 to 2008
$174k
NCI NIH HHS F32 CA123945NCI NIH HHS F32-CA123945NCI NIH HHS R01 CA134571NCI NIH HHS R01-CA134571NIDDK NIH HHS R01 DK063621NIDDK NIH HHS R01-DK63621
6 · The paper itself

Abstract

The past few years have brought new advances in our understanding of the molecular mechanisms underlying the development of Barrett's esophagus and esophageal adenocarcinoma. Although knowledge of the genetic basis for these conditions has not yet translated into clinically useful biomarkers, the current pace of biomedical discovery holds endless possibilities for molecular medicine to improve the diagnosis and management of patients with these conditions. This article provides a useful conceptual basis for understanding the molecular events involved in the making of Barrett metaplasia and in its neoplastic progression, and provides a rationale for evaluating studies on the application of molecular medicine to the diagnosis and management of patients with Barrett's esophagus and esophageal adenocarcinoma.

Indexed as

Cell Transformation, NeoplasticAdenocarcinomaBarrett EsophagusEsophageal NeoplasmsEsophagitisGastroesophageal RefluxHumansPrecancerous ConditionsSignal Transduction

Identifiers

PMID21112495
PMCPMC3052949

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.