ArticleBrain, behavior, and immunity2011
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans.
Article in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed.
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- Serum Lipidome Change in Japanese Patients with Major Depressive Disorder: A Real-World Exploratory Study.Neuropsychiatric disease and treatment · 2025Article
- When High Subjective Social Status Becomes a Burden: A Japan-U.S. Comparison of Biological Health Markers.Personality & social psychology bulletin · 2024Article
- Obesity Is Associated with Increased FEndocrines · 2023Article
- Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.Health psychology review · 2023Article
- Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Culture and Health: Recent Developments and Future Directions.The Japanese psychological research · 2022Article
- Post-Inflammatory Hyperpigmentation in Dark Skin: Molecular Mechanism and Skincare Implications.Clinical, cosmetic and investigational dermatology · 2022Review
- Networks, cultures, and institutions: Toward a social immunology.Brain, behavior, & immunity - health · 2021Article
- Distress Trajectories in Black and White Breast Cancer Survivors: From Diagnosis to Survivorship.Psychoneuroendocrinology · 2021Article
- Immune Inflammation Pathways as Therapeutic Targets to Reduce Lethal Prostate Cancer in African American Men.Cancers · 2021Review
- Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia.Pathogens (Basel, Switzerland) · 2021Article
- An overview of cancer health disparities: new approaches and insights and why they matter.Carcinogenesis · 2021Review
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- Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Racial/ethnic differences in health-related quality of life among Hawaii adult population.Health and quality of life outcomes · 2020Article
- Cultural and life style practices associated with low inflammatory physiology in Japanese adults.Brain, behavior, and immunity · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The pleiotropic cytokine, interleukin-6 (IL-6), has emerged as a key factor in the biology of aging and the physiology of inflammation. Yet much of what we know about the normal functioning of IL-6 has been generated primarily from research on European populations and Americans of European descent. Our analyses compared IL-6 levels in 382 middle-aged and older Japanese to the values found in 1209 Caucasian- and African-Americans from the Midlife in the United States survey (MIDUS). Across the life span from 30 to 80 years of age, mean IL-6 levels were strikingly lower in Japanese individuals. Significantly lower levels of C-reactive protein (CRP) and fibrinogen (FBG) provided confirmatory evidence for a population difference in proinflammatory activity. Because IL-6 release has been associated with obesity, differences in body mass index (BMI) were taken into consideration. Japanese had the lowest, and African-Americans had the highest overall BMIs, but significant group differences in IL-6 persisted even after BMI was included as a covariate in the analyses. Additional support for distinct variation in IL-6 biology was generated when systemic levels of the soluble receptor for IL-6 (sIL-6r) were evaluated. Serum sIL-6r was higher in Japanese than Americans, but was most notably low in African-Americans. Our cytokine data concur with national differences in the prevalence of age-related illnesses linked to inflammatory physiology, including cardiovascular disease. The findings also highlight the importance of broadening the diversity of people included in population studies of health and aging, especially given the relative paucity of information for some Asian countries and on individuals of Asian heritage living in the US.
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Registered trials
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