ArticleBiophysical journal2010
Changes in single K(+) channel behavior induced by a lipid phase transition.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026Review
- Markov models and long-term memory in ion channels: A contradiction in terms?Biophysical journal · 2025Article
- Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia.Frontiers in neuroanatomy · 2024Review
- Biophysical studies of lipid nanodomains using different physical characterization techniques.Biophysical journal · 2023Review
- Malaria parasites release vesicle subpopulations with signatures of different destinations.EMBO reports · 2022Article
- Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission.Membranes · 2021Article
- Spike frequency-dependent inhibition and excitation of neural activity by high-frequency ultrasound.The Journal of general physiology · 2020Article
- Non-linear Conductance, Rectification, and Mechanosensitive Channel Formation of Lipid Membranes.Frontiers in cell and developmental biology · 2020Article
- Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.Ultrasound in medicine & biology · 2019Review
- Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes.Bioscience reports · 2019Article
- Activation of Piezo1 but Not NaUltrasound in medicine & biology · 2018Article
- Assessing Interactions Between a Polytopic Membrane Protein and Lipid Bilayers Using Differential Scanning Calorimetry and Solid-State NMR.The journal of physical chemistry. B · 2018Article
- Chloroform alters interleaflet coupling in lipid bilayers: an entropic mechanism.Journal of the Royal Society, Interface · 2015Article
- Shaped apertures in photoresist films enhance the lifetime and mechanical stability of suspended lipid bilayers.Biophysical journal · 2014Article
- Xenon and other volatile anesthetics change domain structure in model lipid raft membranes.The journal of physical chemistry. B · 2013Article
- Temperature dependence of IP3-mediated local and global Ca2+ signals.Biophysical journal · 2013Article
- Opto-mechanical coupling in interfaces under static and propagative conditions and its biological implications.PloS one · 2013Article
- Robustness of a rhythmic circuit to short- and long-term temperature changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Halothane changes the domain structure of a binary lipid membrane.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Changes in single K channel behavior induced by a lipid phase transition.Communicative & integrative biology · 2011Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show that the activity of an ion channel is correlated with the phase state of the lipid bilayer hosting the channel. By measuring unitary conductance, dwell times, and open probability of the K(+) channel KcsA as a function of temperature in lipid bilayers composed of POPE and POPG in different relative proportions, we obtain that all those properties show a trend inversion when the bilayer is in the transition region between the liquid-disordered and the solid-ordered phase. These data suggest that the physical properties of the lipid bilayer influence ion channel activity likely via a fine-tuning of its conformations. In a more general interpretative framework, we suggest that other parameters such as pH, ionic strength, and the action of amphiphilic drugs can affect the physical behavior of the lipid bilayer in a fashion similar to temperature changes resulting in functional changes of transmembrane proteins.
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