ArticleBiophysical journal2010
Deformation of dynamin helices damped by membrane friction.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission.Developmental cell · 2024Article
- Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Polymer-like Model to Study the Dynamics of Dynamin Filaments on Deformable Membrane Tubes.Biophysical journal · 2019Article
- Dynamic remodeling of the dynamin helix during membrane constriction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Constriction by Dynamin: Elasticity versus Adhesion.Biophysical journal · 2016Article
- Membrane fission by dynamin: what we know and what we need to know.The EMBO journal · 2016Review
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mechanics of dynamin-mediated membrane fission.Annual review of biophysics · 2013Review
- Membrane shape at the edge of the dynamin helix sets location and duration of the fission reaction.Cell · 2012Article
- Crystal structure of nucleotide-free dynamin.Nature · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamin and other proteins of the dynamin superfamily are widely used by cells to sever lipid bilayers. During this process, a short helical dynamin polymer (one to three helical turns) assembles around a membrane tubule and reduces its radius and pitch upon guanosine triphosphate hydrolysis. This deformation is thought to be crucial for dynamin's severing action and results in an observable twisting of the helix. Here, we quantitatively characterize the dynamics of this deformation by studying long dynamin helices (many helical turns). We perform in vitro experiments where we attach small beads to the dynamin helix and track their rotation in real time, thus collecting information about the space and time dependence of the deformation. We develop a theoretical formalism to predict the dynamics of a mechanically continuous helix deforming on long timescales. Longer helices deform more slowly, as predicted by theory. This could account for the previously reported observation that they are less fission-competent. Comparison between experiments and our model indicates that the deformation dynamics is dominated by the draining of the membrane out of the helix, allowing quantification of helix-membrane interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.