ArticleComprehensive psychiatry
Patterns of comorbidity among mental disorders: a person-centered approach.
Article in Comprehensive psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Symptoms of Psychological Stress and Sickness Absence Among Healthcare Workers During a Persistent Crisis.Scandinavian journal of psychology · 2025Observational
- The role of self-stigma in mediating the association between externalizing and treatment-seeking intention.Frontiers in psychology · 2025Article
- The validity of transdiagnostic factors in predicting homotypic and heterotypic continuity of psychopathology symptoms over time.Frontiers in psychiatry · 2023Article
- Psychosocial Profiles of Patients Admitted to Psychiatric Emergency Services: Results from the Signature Biobank Project.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- Protective and Risk Factors at the Intersection of Chronic Pain, Depression, Anxiety, and Somatic Amplification: A Latent Profile Approach.Journal of pain research · 2022Article
- Using density of antecedent events and trajectory path analysis to investigate family-correlated patterns of onset of bipolar I disorder: a comparison of cohorts from Europe and USA.International journal of bipolar disorders · 2021Article
- Attachment to Pets Moderates Transitions in Latent Patterns of Mental Health Following the Onset of the COVID-19 Pandemic: Results of a Survey of U.S. Adults.Animals : an open access journal from MDPI · 2021Article
- A latent class analysis of alcohol and posttraumatic stress symptoms among offspring of parents with and without alcohol use disorder.Addictive behaviors · 2021Article
- The prevalence of mental disorders and patterns of comorbidity within a large sample of mentally ill prisoners: A network analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure.Assessment · 2020Article
- The impact of the overlap between externalizing and internalizing problems on substance use disorders.European child & adolescent psychiatry · 2020Article
- Tobacco use and the interplay of internalizing, externalizing and substance use problems: A latent class analysis of data from the Population Assessment of Tobacco and Health Study.Drug and alcohol dependence · 2019Article
- Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project.Assessment · 2019Article
- Article
- Developmental stability of general and specific factors of psychopathology from early childhood to adolescence: dynamic mutualism or p-differentiation?Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis.Journal of affective disorders · 2017Article
- Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- A hierarchical causal taxonomy of psychopathology across the life span.Psychological bulletin · 2017Review
- The dynamics of internalizing and externalizing comorbidity across the early school years.Development and psychopathology · 2016Article
- Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span.Development and psychopathology · 2016Article
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3 authors.
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Abstract
objectiveComorbidity poses a major challenge to conventional methods of diagnostic classification. Although dimensional models of psychopathology have shed some light on this issue, the reason for interrelationships among dimensions is unclear. The current study employed an alternative approach to characterizing patterns of comorbidity among common mental disorders by modeling them instead as clusters by using latent class analysis (LCA).
methodLatent class analyses of Diagnostic and Statistical Manual of Mental Disorders diagnoses from two nationally representative epidemiological samples--the National Comorbidity Survey and National Comorbidity Survey--Replication datasets--were undertaken.
resultsWithin each dataset, LCA yielded 5 latent classes exhibiting distinctive profiles of diagnostic comorbidity: a fear class (all phobias and panic disorder), a distress class (depression, generalized anxiety disorder, dysthymia), an externalizing class (alcohol and drug dependence, conduct disorder), a multimorbid class (highly elevated rates of all disorders), and a few-disorders class (very low probability of all disorders). Whereas some disorders were relatively specific to certain classes, others (major depression, posttraumatic stress disorder, social phobia) appeared to be evident across all classes. Profiles for the five classes were highly similar across the two samples. When bipolar I disorder was added to the LCA models, in both samples, it occurred almost exclusively in the multimorbid class.
conclusionsComorbidity among mental disorders in the general population appears to occur in a finite number of distinct patterns. This finding has important implications for efforts to refine existing diagnostic classification schemes, as well as for research directed at elucidating the etiology of mental disorders.
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