ArticleProgress in brain research2010
Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals.
Article in Progress in brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Review
- Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 2: TRPM4 in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network.eLife · 2021Article
- Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation.Neuron · 2020Article
- Critical Components for Spontaneous Activity and Rhythm Generation in Spinal Cord Circuits in Culture.Frontiers in cellular neuroscience · 2020Article
- Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.eLife · 2019Article
- Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics.PLoS computational biology · 2019Article
- Article
- Modeling breathing rhythms.eLife · 2019Article
- Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.PLoS biology · 2019Article
- Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive.Frontiers in physiology · 2019Article
- Kinetic properties of persistent NaThe Journal of general physiology · 2018Article
- Defining the Rhythmogenic Elements of Mammalian Breathing.Physiology (Bethesda, Md.) · 2018Review
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Respiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta).Respiratory physiology & neurobiology · 2016Article
- Robust network oscillations during mammalian respiratory rhythm generation driven by synaptic dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- An astrocyte-dependent mechanism for neuronal rhythmogenesis.Nature neuroscience · 2015Article
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6 authors.
Funding
Abstract
Breathing, chewing, and walking are critical life-sustaining behaviors in mammals that consist essentially of simple rhythmic movements. Breathing movements in particular involve the diaphragm, thorax, and airways but emanate from a network in the lower brain stem. This network can be studied in reduced preparations in vitro and using simplified mathematical models that make testable predictions. An iterative approach that employs both in vitro and in silico models argues against canonical mechanisms for respiratory rhythm in neonatal rodents that involve reciprocal inhibition and pacemaker properties. We present an alternative model in which emergent network properties play a rhythmogenic role. Specifically, we show evidence that synaptically activated burst-generating conductances-which are only available in the context of network activity-engender robust periodic bursts in respiratory neurons. Because the cellular burst-generating mechanism is linked to network synaptic drive we dub this type of system a group pacemaker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.