Evidence map›Paper›PMID 21111071›Full record

ArticleActa biomaterialia2011

Differences between top-down and bottom-up approaches in mineralizing thick, partially demineralized collagen scaffolds.

Yan Liu, Sui Mai, Nan Li, Cynthia K Y Yiu, Jing Mao, David H Pashley, Franklin R Tay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  15. [Effect of bioactive glass pretreatment on the durability of dentin bonding interface].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020
    Article
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  20. [Progress on matrix metalloproteinase inhibitors].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Yan LiuDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sui Mai
Nan Li
Cynthia K Y Yiu
Jing Mao
David H Pashley
Franklin R Tay
Augusta University · USTongji Hospital · CNFujian University of Traditional Chinese Medicine · CNSun Yat-sen University · CNUniversity of Hong Kong · HK

Funding

Biomimetic remineralization of resin-dentin bondsR21DE019213 · NIDCR · AUGUSTA UNIVERSITY · PI TAY, FRANKLIN CHI MENG · 2009 to 2010
$362k
NIDCR NIH HHS R21 DE019213NIDCR NIH HHS R21 DE019213-01
6 · The paper itself

Abstract

Biominerals exhibit complex hierarchical structures derived from bottom-up self-assembly mechanisms. Type I collagen serves as the building block for mineralized tissues such as bone and dentin. In the present study, 250-300 μm thick, partially demineralized collagen scaffolds exhibiting a gradient of demineralization from the base to surface were mineralized using a classical top-down approach and a non-classical bottom-up approach. The top-down approach involved epitaxial growth over seed crystallites. The bottom-up approach utilized biomimetic analogs of matrix proteins to stabilize amorphous calcium phosphate nanoprecursors and template apatite nucleation and growth within the collagen matrix. Micro-computed tomography and transmission electron microscopy were employed to examine mineral uptake and apatite arrangement within the mineralized collagen matrix. The top-down approach could mineralize only the base of the partially demineralized scaffold, where remnant seed crystallites were abundant. Minimal mineralization was observed along the surface of the scaffold; extrafibrillar mineralization was predominantly observed. Conversely, the entire partially demineralized scaffold, including apatite-depleted collagen fibrils, was mineralized by the bottom-up approach, with evidence of both intrafibrillar and extrafibrillar mineralization. Understanding the different mechanisms involved in these two mineralization approaches is pivotal in adopting the optimum strategy for fabricating novel nanostructured materials in bioengineering research.

Indexed as

CollagenHumansHydrogen-Ion ConcentrationMineralsNanotechnologyTime FactorsTissue ScaffoldsCollagenMinerals

Identifiers

PMID21111071
PMCPMC3050119
OpenAlexW1997114625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.