ArticlePharmacology, biochemistry, and behavior2011
Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers.
Article in Pharmacology, biochemistry, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies.Molecular psychiatry · 2026Pooled it
- Effects of acute alcohol administration on working memory: a systematic review and meta-analysis.Psychopharmacology · 2022Pooled it
- Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial.The American journal of psychiatry · 2026Trial
- Effects of cannabis use on alcohol consumption in a sample of treatment-engaged heavy drinkers in Colorado.Addiction (Abingdon, England) · 2021Trial
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
- ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Safety of Co-Administered Cannabidiol (CBD) and alcohol: a Phase I study.Journal of cannabis research · 2026Article
- Effects of legal-market cannabis and alcohol on verbal learning and memory.Psychopharmacology · 2026Article
- Derivation of a health-based guidance value for ΔEFSA journal. European Food Safety Authority · 2025Article
- Cannabis administration is associated with reduced alcohol consumption: Evidence from a novel laboratory co-administration paradigm.Drug and alcohol dependence · 2025Article
- The association between cannabis and alcohol co-use and momentary subjective effects: Risks for increasingly hazardous cannabis use.Drug and alcohol dependence · 2025Article
- Is there a relationship between abuse of alcohol and illicit drugs seen in hair results?Drug testing and analysis · 2025Article
- Examining the Impact of Simultaneous Alcohol and Cannabis Use on Alcohol Consumption and Consequences: Protocol for an Observational Ambulatory Assessment Study in Young Adults.JMIR research protocols · 2024Article
- The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies.Alcohol, clinical & experimental research · 2024Review
- ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting.Current pain and headache reports · 2023Review
- Simultaneous fatal poisoning of two victims with 4F-MDMB-BINACA and ethanol.Forensic toxicology · 2023Article
- Cannabis use and subjective response to alcohol in the human laboratory.Drug and alcohol dependence · 2022Article
- Protocol for a mobile laboratory study of co-administration of cannabis concentrates with a standard alcohol dose in humans.PloS one · 2022Article
- Patterns of Cannabis and Alcohol Co-Use: Substitution Versus Complementary Effects.Alcohol research : current reviews · 2022Review
- Sex-dependent effects of alcohol administration on the urge to use cannabis.Experimental and clinical psychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationalePrevious studies examining the combined effects of ethanol and cannabis, or its primary psychoactive ingredient, ∆⁹-tetrahydrocannabinol (THC), have provided mixed results. Data from an in vitro study suggests that combined, sub-threshold doses of these drugs may interact to produce synergistic effects. Very low doses of the two drugs in combination have not been tested in humans. MATERIALS AND
methodsThis study assessed whether combinations of acute, very low doses of ethanol and THC produce synergistic effects on subjective, cognitive, and physiological measures. Healthy volunteers (n=11) received capsules containing placebo or THC (2.5 mg), and beverages containing placebo or ethanol (0.1 and 0.2 g/kg) alone, and in combination, across separate sessions, in a within-subjects, randomized, double-blind design. During each session, participants completed measures of working memory, psychomotor ability, and simple reaction time, and provided subjective mood and drug effect ratings. Cardiovascular measures were obtained at regular intervals.
resultsAs intended, when administered alone, these very low doses of ethanol and THC had only moderate effects on isolated measures. The combined effects of these drugs were not synergistic, and in some cases appeared to be less-than-additive.
conclusionsOur data provide no evidence for synergistic effects of acute combinations of very-low-dose ethanol and THC on subjective or physiologic response, or on cognitive performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.