ArticleMolecular neurodegeneration2010
Age-related synaptic loss of the medial olivocochlear efferent innervation.
Article in Molecular neurodegeneration, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Age-related changes in olivocochlear efferent innervation in gerbils.Frontiers in synaptic neuroscience · 2024Article
- Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.PLoS biology · 2023Article
- Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy.Hearing research · 2022Article
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?Expert opinion on therapeutic targets · 2022Review
- Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem.Frontiers in cellular neuroscience · 2022Article
- Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice.Frontiers in aging neuroscience · 2021Article
- Preventing presbycusis in mice with enhanced medial olivocochlear feedback.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effects of Non-traumatic Noise and Conductive Hearing Loss on Auditory System Function.Neuroscience · 2019Review
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- The effects of preceding sound and stimulus duration on measures of suppression in younger and older adults.The Journal of the Acoustical Society of America · 2018Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice.Frontiers in neuroscience · 2017Article
- Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus).Frontiers in aging neuroscience · 2015Article
- Age related changes to the dynamics of contralateral DPOAE suppression in human subjects.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2014Article
- Communication breakdown: the impact of ageing on synapse structure.Ageing research reviews · 2014Review
- Aging of the medial olivocochlear reflex and associations with speech perception.The Journal of the Acoustical Society of America · 2014Article
- Article
- Efferent synapses return to inner hair cells in the aging cochlea.Neurobiology of aging · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Age-related functional decline of the nervous system is consistently observed, though cellular and molecular events responsible for this decline remain largely unknown. One of the most prevalent age-related functional declines is age-related hearing loss (presbycusis), a major cause of which is the loss of outer hair cells (OHCs) and spiral ganglion neurons. Previous studies have also identified an age-related functional decline in the medial olivocochlear (MOC) efferent system prior to age-related loss of OHCs. The present study evaluated the hypothesis that this functional decline of the MOC efferent system is due to age-related synaptic loss of the efferent innervation of the OHCs. To this end, we used a recently-identified transgenic mouse line in which the expression of yellow fluorescent protein (YFP), under the control of neuron-specific elements from the thy1 gene, permits the visualization of the synaptic connections between MOC efferent fibers and OHCs. In this model, there was a dramatic synaptic loss between the MOC efferent fibers and the OHCs in older mice. However, age-related loss of efferent synapses was independent of OHC status. These data demonstrate for the first time that age-related loss of efferent synapses may contribute to the functional decline of the MOC efferent system and that this synaptic loss is not necessary for age-related loss of OHCs.
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Registered trials
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