Trial reportBMC psychiatry2010
The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder.
Trial report in BMC psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00845260 (Internet- Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder in a Psychiatric Setting), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Internet- Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder in a Psychiatric Setting: A Randomized Equivalence Trial
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.Psychiatric genetics · 2014Pooled it
- Trial
- Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- 5HTT is associated with the phenotype psychological flexibility: results from a randomized clinical trial.European archives of psychiatry and clinical neuroscience · 2015Trial
- Catehol-o-methyltransferase gene Val158met polymorphism as a potential predictor of response to computer-assisted delivery of cognitive-behavioral therapy among cocaine-dependent individuals: Preliminary findings from a randomized controlled trial.The American journal on addictions · 2015Trial
- Maximizing the utility of a single site randomized controlled psychotherapy trial.Contemporary clinical trials · 2015Trial
- Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?Translational psychiatry · 2014Trial
- The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.Biological psychiatry · 2013Trial
- Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder.PloS one · 2013Trial
- Application and Mechanisms of Internet-Based Cognitive Behavioral Therapy (iCBT) in Improving Psychological State in Cancer Patients.Journal of Cancer · 2023Review
- Psychotherapies and digital interventions for OCD in adults: What do we know, what do we need still to explore?Comprehensive psychiatry · 2023Review
- Pharmacological Implications of Adjusting Abnormal Fear Memory: Towards the Treatment of Post-Traumatic Stress Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Review
- Maximizing remission from cognitive-behavioral therapy in medicated adults with obsessive-compulsive disorder.Behaviour research and therapy · 2021Article
- Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System.Frontiers in pharmacology · 2019Review
- Internet interventions: Past, present and future.Internet interventions · 2018Article
- Multilevel impact of the dopamine system on the emotion-potentiated startle reflex.Psychopharmacology · 2015Article
- Generation and characterization of humanized mice carrying COMT158 Met/Val alleles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive behavioral therapy (CBT) represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met) in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting.
methodsWe tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients.
resultsWe present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based) CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material.
conclusionsWe were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed.
trial registrationClinical Trial Registry name: Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder (IP2). Registration Identification number: NCT00845260, http://www.clinicaltrials.gov/ct2/show/NCT00845260.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.