ArticleJournal of proteome research2011
Glycoproteomic analysis of glioblastoma stem cell differentiation.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The T/Tn-SpecificCancers · 2021Article
- Fibronectin Promotes the Malignancy of Glioma Stem-Like Cells Via Modulation of Cell Adhesion, Differentiation, Proliferation and Chemoresistance.Frontiers in molecular neuroscience · 2018Article
- Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer.Journal of proteomics & bioinformatics · 2016Article
- Tenascin-C: a novel candidate marker for cancer stem cells in glioblastoma identified by tissue microarrays.Journal of proteome research · 2015Article
- Sialidase NEU4 is involved in glioblastoma stem cell survival.Cell death & disease · 2014Article
- Molecular imaging of oral premalignant and malignant lesions using fluorescently labeled lectins.Translational oncology · 2014Article
- Identification of novel tumor-associated cell surface sialoglycoproteins in human glioblastoma tumors using quantitative proteomics.PloS one · 2014Article
- Analysis of glycoproteins for biomarker discovery.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Discrimination of colon cancer stem cells using noncanonical amino acid.Chemical communications (Cambridge, England) · 2012Article
- CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays.Molecular & cellular proteomics : MCP · 2012Article
- Identification of glycoprotein markers for pancreatic cancer CD24+CD44+ stem-like cells using nano-LC-MS/MS and tissue microarray.Journal of proteome research · 2012Article
- Deeply dissecting stemness: making sense to non-coding RNAs in stem cells.Stem cell reviews and reports · 2012Review
- Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor.Proteomics · 2011Article
- Method for novel anti-cancer drug development using tumor explants of surgical specimens.Journal of visualized experiments : JoVE · 2011Article
- Quantitative mass spectrometric analysis of glycoproteins combined with enrichment methods.Mass spectrometry reviewsReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Cancer stem cells are responsible for tumor formation through self-renewal and differentiation into multiple cell types and thus represent a new therapeutic target for tumors. Glycoproteins play a critical role in determining the fates of stem cells such as self-renewal, proliferation, and differentiation. Here we applied a multilectin affinity chromatography and quantitative glycoproteomics approach to analyze alterations of glycoproteins relevant to the differentiation of a glioblastoma-derived stem cell line HSR-GBM1. Three lectins including concanavalin A (Con A), wheat germ agglutinin (WGA), and peanut agglutinin (PNA) were used to capture glycoproteins, followed by LC-MS/MS analysis. A total of 73 and 79 high-confidence (FDR < 0.01) glycoproteins were identified from the undifferentiated and differentiated cells, respectively. Label-free quantitation resulted in the discovery of 18 differentially expressed glycoproteins, wherein 9 proteins are localized in the lysosome. All of these lysosomal glycoproteins were up-regulated after differentiation, where their principal function was hydrolysis of glycosyl residues. Protein-protein interaction and functional analyses revealed the active involvement of lysosomes during the process of glioblastoma stem cell differentiation. This work provides glycoprotein markers to characterize differentiation status of glioblastoma stem cells that may be useful in stem-cell therapy of glioblastoma.
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Registered trials
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