ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2011
Identifying roles for neurotransmission in circuit assembly: insights gained from multiple model systems and experimental approaches.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Maturation of Complex Synaptic Connections of Layer 5 Cortical Axons in the Posterior Thalamic Nucleus Requires SNAP25.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit.Scientific reports · 2021Article
- Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.Nature communications · 2019Article
- Synaptogenesis and synaptic protein localization in the postnatal development of rod bipolar cell dendrites in mouse retina.The Journal of comparative neurology · 2019Article
- GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.Cell reports · 2018Article
- A Unique Homeostatic Signaling Pathway Links Synaptic Inactivity to Postsynaptic mTORC1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.Chemical senses · 2017Review
- Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.Nature neuroscience · 2017Article
- A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons.Scientific reports · 2017Article
- Loss of Neuroligin3 specifically downregulates retinal GABAAα2 receptors without abolishing direction selectivity.PloS one · 2017Article
- Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.Cell reports · 2015Article
- Retrograde plasticity and differential competition of bipolar cell dendrites and axons in the developing retina.Current biology : CB · 2014Article
- Neuronal remodeling in retinal circuit assembly, disassembly, and reassembly.Trends in neurosciences · 2014Review
- Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.Neuron · 2014Review
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
- The role of neuronal activity and transmitter release on synapse formation.Current opinion in neurobiology · 2014Review
- Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo.Neuron · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In the adult nervous system, chemical neurotransmission between neurons is essential for information processing. However, neurotransmission is also important for patterning circuits during development, but its precise roles have yet to be identified, and some remain highly debated. Here, we highlight viewpoints that have come to be widely accepted or still challenged. We discuss how distinct techniques and model systems employed to probe the developmental role of neurotransmission may reconcile disparate ideas. We underscore how the effects of perturbing neurotransmission during development vary with model systems, the stage of development when transmission is altered, the nature of the perturbation, and how connectivity is assessed. Based on findings in circuits with connectivity arranged in layers, we raise the possibility that there exist constraints in neuronal network design that limit the role of neurotransmission. We propose that activity-dependent mechanisms are effective in refining connectivity patterns only when inputs from different cells are close enough, spatially, to influence each other's outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.