ArticleCerebellum (London, England)2011
The neural substrate of predictive motor timing in spinocerebellar ataxia.
Article in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).Neurobiology of disease · 2025Article
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).bioRxiv : the preprint server for biology · 2024Article
- The underpinnings of cerebellar ataxias.Clinical neurophysiology practice · 2022Review
- Modulation of cerebellar brain inhibition during temporal adaptive learning in a coincident timing task.Experimental brain research · 2021Article
- Cerebellum, Basal Ganglia, and Cortex Mediate Performance of an Aerial Pursuit Task.Frontiers in human neuroscience · 2020Article
- Grip force preparation for collisions.Experimental brain research · 2019Article
- Characteristics of Tremor Induced by Lesions of the Cerebellum.Cerebellum (London, England) · 2019Article
- Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy.Cerebellum (London, England) · 2019Article
- Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor.Cerebellum (London, England) · 2019Article
- Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum.Cerebellum (London, England) · 2019Article
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons.Frontiers in molecular neuroscience · 2019Article
- The mystery of the cerebellum: clues from experimental and clinical observations.Cerebellum & ataxias · 2018Review
- Individual differences in cognitive reappraisal use and emotion regulatory brain function in combat-exposed veterans with and without PTSD.Depression and anxiety · 2017Article
- Taxonomies of Timing: Where Does the Cerebellum Fit In?Current opinion in behavioral sciences · 2016Article
- Impaired Spatio-Temporal Predictive Motor Timing Associated with Spinocerebellar Ataxia Type 6.PloS one · 2016Article
- Neural Network of Predictive Motor Timing in the Context of Gender Differences.Neural plasticity · 2016Article
- Proceedings of the workshop on Cerebellum, Basal Ganglia and Cortical Connections Unmasked in Health and Disorder held in Brno, Czech Republic, October 17th, 2013.Cerebellum (London, England) · 2015Article
- Abnormalities in myelination of the superior cerebellar peduncle in patients with schizophrenia and deficits in movement sequencing.Cerebellum (London, England) · 2014Article
- New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas. The superior performance in the controls was related to activation in thalamus, putamen (lentiform nucleus) and cerebellum (right dentate nucleus and culmen-lobule IV), which were not activated either in the spinocerebellar subjects or within a subgroup of controls who performed poorly. Both the cerebellum and the basal ganglia are necessary for the predictive motor timing. The degeneration of the cerebellum associated with spinocerebellar types 6 and 8 appears to lead to quantitative rather than qualitative deficits in temporal processing. The lack of any areas with greater activity in the spinocerebellar group than in controls suggests that limited functional reorganization occurs in this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.