Evidence map›Paper›PMID 21110107›Full record

ArticleMolecular biology reports2011

Long-term intraperitoneal injection of lipopolysaccharide induces high expression of Id2 in the brain of mice.

Le-Yu Wang, Zeng-zhi Niu, Bian-xiang Hu, Jia-ming Wu, Xuan Jiang, Xiao-fang Hu, Wen-hua Huang, Jun Ouyang, Lei Yu, Xiao-Zhong Qiu

Abstract read
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In one paragraph

Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Le-Yu WangDepartment of Anatomy, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zeng-zhi Niu
Bian-xiang Hu
Jia-ming Wu
Xuan Jiang
Xiao-fang Hu
Wen-hua Huang
Jun Ouyang
Lei Yu
Xiao-Zhong Qiu
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipopolysaccharide (LPS) from gram negative bacteria plays an important role in the pathophysiology of neurodegenerative diseases. Many evidences showed that LPS-induced neuroinflammation is related to upregulation of NF-kappaB. Here, we report that long-term treatment of lower dosage LPS mainly causes upregulation of Id2 protein. As an inhibitor of cell differentiation, Id2 plays an import role in adult olfactory neurogenesis. However, Id2 protein in brain acts as two edges in a sword, persist over-expression of Id2 in brain can induce neurodamages and may be related to neurodegeneration.

Indexed as

AnimalsBenzimidazolesBlotting, WesternBrainCell DeathGene Expression RegulationInhibitor of Differentiation Protein 2Injections, IntraperitonealLipopolysaccharidesMiceMice, Inbred C57BLPropidiumReverse Transcriptase Polymerase Chain ReactionTime FactorsBenzimidazolesbisbenzimide ethoxide trihydrochlorideIdb2 protein, mouseInhibitor of Differentiation Protein 2LipopolysaccharidesPropidium

Identifiers

PMID21110107
OpenAlexW2027525712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.