ArticleEuropean biophysics journal : EBJ2011
Dielectrophoretic stretching of cells allows for characterization of their mechanical properties.
Article in European biophysics journal : EBJ, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- PPy-Coated Wire Actuators for the Micromechanostimulation of Cells: Fabrication and Characterization.Small science · 2026Article
- Experimental extraction of Young's modulus of MCF-7 tissue using atomic force microscopy and the spherical contact models.European biophysics journal : EBJ · 2023Article
- Quantifying Deformation and Migration Properties of U87 Glioma Cells Using Dielectrophoretic Forces.Biosensors · 2022Article
- Label-Free Enrichment of Circulating Tumor Plasma Cells: Future Potential Applications of Dielectrophoresis in Multiple Myeloma.International journal of molecular sciences · 2022Review
- Gradient-based impedance synthesis for breast and lung cancer cell screening deploying planar and nano-structured electrodes.Medical & biological engineering & computing · 2021Article
- Single-cell mechanical analysis and tension quantification via electrodeformation relaxation.Physical review. E · 2021Article
- Cell properties assessment using optimized dielectrophoresis-based cell stretching and lumped mechanical modeling.Scientific reports · 2021Article
- Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels Towards Cartilage Tissue Engineering by Electrical Stimulation.Molecules (Basel, Switzerland) · 2020Article
- Hybrid analytical-numerical approach for investigation of differential effects in normal and cancer cells under electroporation.RSC advances · 2019Article
- New MEMS Tweezers for the Viscoelastic Characterization of Soft Materials at the Microscale.Micromachines · 2017Article
- An inverted dielectrophoretic device for analysis of attached single cell mechanics.Lab on a chip · 2016Article
- Quantitative Biomechanics of Healthy and Diseased Human Red Blood Cells using Dielectrophoresis in a Microfluidic System.Extreme Mechanics Letters · 2014Article
- Viscoelasticity as a biomarker for high-throughput flow cytometry.Biophysical journal · 2013Article
- Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potential.Clinical & experimental metastasis · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
The mechanical behavior of biological cells is mainly determined by the cytoskeleton. Its properties are closely interlinked with many cellular events, including disease-related processes, and, thus, may be exploited as potent biomarkers. We have stretched two types of cells between microelectrodes through the application of dielectrophoretic forces. Small numbers of cells of cancerous origin (MCF-7) and from related noncancerous tissue (MCF-10A) were sufficient to obtain data that allowed us to unambiguously distinguish these cells. The Maxwell tension applied has been estimated to be 56 Pa. A detailed analysis of the cells showed that the differences in the stretching response are due to cell-specific mechanical properties. Through the addition of an actin- and a microtubule-specific toxin to the cells, differences in the microtubular structures of the two cell types have been identified as the major cause for the behavior observed. Our approach shows enormous potential for parallelization and automation. Hence, it should be suitable for achieving throughputs that make it attractive for many biomedical diagnostic purposes.
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