ArticleDiabetologia2011
Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.Diabetes care · 2023Pooled it
- The Prevalence of Obesity Among Children With Type 2 Diabetes: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Pooled it
- Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.Diabetologia · 2012Pooled it
- From Metabolic Syndrome to Type 2 Diabetes in Youth.Children (Basel, Switzerland) · 2023Review
- Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Incidence Trends of Type 2 Diabetes Mellitus, Medication-Induced Diabetes, and Monogenic Diabetes in Canadian Children, Then (2006-2008) and Now (2017-2019).Pediatric diabetes · 2023Article
- The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead.The Journal of pediatrics · 2022Article
- Diabetes in Youth: A Global Perspective.Endocrinology and metabolism clinics of North America · 2021Review
- The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.Diabetes · 2021Article
- A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors.Frontiers in endocrinology · 2021Article
- Impact of type 2 diabetes variants identified through genome-wide association studies in early-onset type 2 diabetes from South Indian population.Genomics & informatics · 2020Article
- Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.Molecular metabolism · 2019Article
- Traditional knowledge-based lifestyle interventions in the prevention of obesity and type 2 diabetes in Indigenous children in Canada: a systematic review protocol.Systematic reviews · 2019Article
- Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association.Diabetes care · 2018Review
- Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.The Lancet. Child & adolescent health · 2018Observational
- Advances in the Genetics of Youth-Onset Type 2 Diabetes.Current diabetes reports · 2018Review
- Article
- Racial Disparities in the Pathogenesis of Type 2 Diabetes and its Subtypes in the African Diaspora: A New Paradigm.Journal of racial and ethnic health disparities · 2016Article
- The SEARCH for Diabetes in Youth study: rationale, findings, and future directions.Diabetes care · 2014Review
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
aim/hypothesisCommon variants in the transcription factor 7-like 2 (TCF7L2) gene have been associated with type 2 diabetes in adults. However, it is not known whether TCF7L2 variation increases the risk of early onset type 2 diabetes. Using a case-control design, we examined whether the reported variants [rs12255372 (T/G) and rs7903146 (T/C)] are associated with type 2 diabetes in SEARCH for Diabetes in Youth study participants.
methodsVariants were genotyped in 694 non-Hispanic white (NHW) youth (86 cases, mean age 15.5 years, mean BMI 34.8; and 608 controls, mean age 14.4 years, mean BMI 22.3) and 545 African-American (AA) youth (154 cases, mean age 15.9, mean BMI 37; and 391 controls, mean age 14.8, mean BMI 23.8). Logistic regression adjusted for age, sex, BMI and West African ancestry.
resultsThe association of the risk T allele with case/control status was different in AA and NHW youth (p = 0.025). Among AA youth, each copy of the T allele (rs7903146) was associated with a 1.97-fold (1.37, 2.82) increased odds for type 2 diabetes (p < 0.0001), after adjustment for age, sex, BMI and African ancestry. No significant association was detected in NHW youth (adjusted OR, 1.14; 0.73, 1.79). CONCLUSION/
interpretationTCF7L2 variation is associated with an increased risk of early-onset type 2 diabetes among AA youth, and the association appears to be stronger in AA than NHW youth. This suggests potential different contributions of genetic and environmental factors to early-onset type 2 diabetes by race.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.