ArticleDiabetologia2011
Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03063229 (Energy Balance Following Islet Transplantation), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Energy Balance Following Islet Transplantation
Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management.Frontiers in endocrinology · 2026Review
- Cerebrovascular complications of diabetes: focus on cognitive dysfunction.Clinical science (London, England : 1979) · 2016Review
- Cerebral Ketone Body Oxidation Is Facilitated by a High Fat Diet Enriched with Advanced Glycation End Products in Normal and Diabetic Rats.Frontiers in neuroscience · 2016Article
- Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship?Neuromolecular medicine · 2014Review
- Differential production of reactive oxygen species in distinct brain regions of hypoglycemic mice.Metabolic brain disease · 2014Article
- Patients with type 1 diabetes exhibit altered cerebral metabolism during hypoglycemia.The Journal of clinical investigation · 2013Article
- Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.PloS one · 2013Article
- Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats.Journal of neuroinflammation · 2012Article
- Cerebrovascular complications of diabetes: focus on stroke.Endocrine, metabolic & immune disorders drug targets · 2012Review
- Hypoglycemia, diabetes, and cardiovascular disease.Diabetes technology & therapeutics · 2012Review
- Is cognitive impairment the fourth diabetic microvascular complication?Journal of diabetes investigation · 2011Article
- Neural dysfunction and retinopathy in persons with type 1 diabetes.Ophthalmic epidemiologyArticle
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study has allowed an examination of the long-term effects of type 1 diabetes and intensity of treatment on cognitive function. The association observed between chronic hyperglycaemia and mild cognitive dysfunction, affecting motor speed and psychomotor efficiency, has been re-evaluated by Jacobson et al. (Diabetologia doi: 10.1007/s00125-010-1883-9) to determine the possible contribution of macrovascular risk factors, subclinical macrovascular disease and microvascular complications (retinopathy and nephropathy). This has revealed associations between mild impairment of psychomotor efficiency and hypertension, glycaemic control and the presence of retinopathy and nephropathy, while smoking history was associated with modest abnormalities in several cognitive domains. Neither macrovascular risk factors nor a history of severe hypoglycaemia was associated with the cognitive decrements; cerebral microangiopathy has been proposed as a possible underlying cause. Although the degree of cognitive impairment was mild and limited to a few domains, these decrements may influence the performance of everyday activities, such as driving.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.