Trial reportCerebral cortex (New York, N.Y. : 1991)2011
Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words.
Trial report in Cerebral cortex (New York, N.Y. : 1991), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- Separating the forest from the palm trees: Individual variation in a presurgical language mapping task.NeuroImage. Clinical · 2026Article
- Neural network dynamics associated with facial and subjective emotional responses.Communications biology · 2025Article
- Functional divergence between the two cerebral hemispheres contributes to human fluid intelligence.Communications biology · 2025Article
- Neural correlates of suppressing and imagining future threat.Scientific reports · 2025Article
- Interhemispheric integration in the neural face perception network: Does stimulus location matter?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- A connectivity model of the anatomic substrates underlying Gerstmann syndrome.Brain communications · 2022Article
- Article
- Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy.Brain sciences · 2021Article
- Characterizing Network Search Algorithms Developed for Dynamic Causal Modeling.Frontiers in neuroinformatics · 2021Article
- A guide to group effective connectivity analysis, part 1: First level analysis with DCM for fMRI.NeuroImage · 2019Article
- A guide to group effective connectivity analysis, part 2: Second level analysis with PEB.NeuroImage · 2019Article
- Amygdala activation during unconscious visual processing of food.Scientific reports · 2019Article
- Interhemispheric connectivity during lateralized lexical decision.Human brain mapping · 2019Article
- Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- "Neural overlap of L1 and L2 semantic representations across visual and auditory modalities: a decoding approach".Neuropsychologia · 2018Article
- Language lateralization during the Chinese semantic task relates to the contralateral cerebra-cerebellar interactions at rest.Scientific reports · 2017Article
- Bidirectional electric communication between the inferior occipital gyrus and the amygdala during face processing.Human brain mapping · 2017Article
- Methodological considerations in assessment of language lateralisation with fMRI: a systematic review.PeerJ · 2017Article
- Charting the effects of TMS with fMRI: Modulation of cortical recruitment within the distributed network supporting semantic control.Neuropsychologia · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Over 90% of people activate the left hemisphere more than the right hemisphere for language processing. Here, we show that the degree to which language is left lateralized is inversely related to the degree to which left frontal regions drive activity in homotopic right frontal regions. Lateralization was assessed in 60 subjects using functional magnetic resonance imaging (fMRI) activation for semantic decisions on verbal (written words) and nonverbal (pictures of objects) stimuli. Regional interactions between left and right ventral and dorsal frontal regions were assessed using dynamic causal modeling (DCM), random-effects Bayesian model selection at the family level, and Bayesian model averaging at the connection level. We found that 1) semantic decisions on words and pictures modulated interhemispheric coupling between the left and right dorsal frontal regions, 2) activation was more left lateralized for words than pictures, and 3) for words only, left lateralization was greater when the coupling from the left to right dorsal frontal cortex was reduced. These results have theoretical implications for understanding how left and right hemispheres communicate with one another during the processing of lateralized functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.