ArticleAmerican journal of human genetics2010
Estimators of the human effective sex ratio detect sex biases on different timescales.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- The Breeding Sex Ratio Interacts With Demographic History to Shape Comparative Patterns of Variation on the X Chromosome and the Autosomes.Genome biology and evolution · 2025Article
- Comparative Patterns of Variation on the X Chromosome and Autosomes: The Role of the Breeding Sex Ratio.bioRxiv : the preprint server for biology · 2025Article
- Genetic and linguistic comparisons reveal complex sex-biased transmission of language features.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Allele frequency dynamics under sex-biased demography and sex-specific inheritance in a pedigreed jay population.Genetics · 2024Article
- Identity-by-descent-based estimation of the X chromosome effective population size with application to sex-specific demographic history.G3 (Bethesda, Md.) · 2023Article
- Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The inference of sex-biased human demography from whole-genome data.PLoS genetics · 2019Article
- Complex patterns of sex-biased demography in canines.Proceedings. Biological sciences · 2019Article
- Deleterious variation shapes the genomic landscape of introgression.PLoS genetics · 2018Article
- Outstanding questions in the study of archaic hominin admixture.PLoS genetics · 2018Review
- Contrasting Patterns of Genomic Diversity Reveal Accelerated Genetic Drift but Reduced Directional Selection on X-Chromosome in Wild and Domestic Sheep Species.Genome biology and evolution · 2018Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Inferring sex-specific demographic history from SNP data.PLoS genetics · 2018Article
- Ancient X chromosomes reveal contrasting sex bias in Neolithic and Bronze Age Eurasian migrations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- The genetic history of Cochin Jews from India.Human genetics · 2016Article
- The Genetics of Bene Israel from India Reveals Both Substantial Jewish and Indian Ancestry.PloS one · 2016Article
- Beyond 2/3 and 1/3: The Complex Signatures of Sex-Biased Admixture on the X Chromosome.Genetics · 2015Article
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3 authors.
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Abstract
Determining historical sex ratios throughout human evolution can provide insight into patterns of genomic variation, the structure and composition of ancient populations, and the cultural factors that influence the sex ratio (e.g., sex-specific migration rates). Although numerous studies have suggested that unequal sex ratios have existed in human evolutionary history, a coherent picture of sex-biased processes has yet to emerge. For example, two recent studies compared human X chromosome to autosomal variation to make inferences about historical sex ratios but reached seemingly contradictory conclusions, with one study finding evidence for a male bias and the other study identifying a female bias. Here, we show that a large part of this discrepancy can be explained by methodological differences. Specifically, through reanalysis of empirical data, derivation of explicit analytical formulae, and extensive simulations we demonstrate that two estimators of the effective sex ratio based on population structure and nucleotide diversity preferentially detect biases that have occurred on different timescales. Our results clarify apparently contradictory evidence on the role of sex-biased processes in human evolutionary history and show that extant patterns of human genomic variation are consistent with both a recent male bias and an earlier, persistent female bias.
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