ArticleAmerican journal of human genetics2010
Population differences in the rate of proliferation of international HapMap cell lines.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Removing unwanted variation between samples in Hi-C experiments.Briefings in bioinformatics · 2024Article
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- Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity.The pharmacogenomics journal · 2019Article
- Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.eLife · 2014Article
- Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.American journal of human genetics · 2014Article
- Silent polymorphisms in the RYR1 gene do not modify the phenotype of the p.4898 I>T pathogenic mutation in central core disease: a case report.BMC research notes · 2014Article
- Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.PloS one · 2014Article
- Functional consequences of PRPF39 on distant genes and cisplatin sensitivity.Human molecular genetics · 2012Article
- Article
- Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Novel lymphoblastoid cell lines from primary neoplasms of the upper aero-digestive tract.The Indian journal of medical research · 2012Article
- Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer.PLoS genetics · 2012Article
- Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor.BMC genomics · 2011Article
- Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The International HapMap Project is a resource for researchers containing genotype, sequencing, and expression information for EBV-transformed lymphoblastoid cell lines derived from populations across the world. The expansion of the HapMap beyond the four initial populations of Phase 2, referred to as Phase 3, has increased the sample number and ethnic diversity available for investigation. However, differences in the rate of cellular proliferation between the populations can serve as confounders in phenotype-genotype studies using these cell lines. Within the Phase 2 populations, the JPT and CHB cell lines grow faster (p < 0.0001) than the CEU or YRI cell lines. Phase 3 YRI cell lines grow significantly slower than Phase 2 YRI lines (p < 0.0001), with no widespread genetic differences based on common SNPs. In addition, we found significant growth differences between the cell lines in the Phase 2 ASN populations and the Han Chinese from the Denver metropolitan area panel in Phase 3 (p < 0.0001). Therefore, studies that separate HapMap panels into discovery and replication sets must take this into consideration.
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