ArticleCell metabolism2010
Lipotoxicity and the development of heart failure: moving from mouse to man.
Article in Cell metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- HeterozygousJournal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2023Review
- Identify Tcea3 as a novel anti-cardiomyocyte hypertrophy gene involved in fatty acid oxidation and oxidative stress.Frontiers in cardiovascular medicine · 2023Article
- SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.Circulation research · 2022Article
- Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration.Scientific reports · 2021Article
- Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ.Frontiers in endocrinology · 2021Review
- Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.Cell death & disease · 2020Article
- Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus.Theranostics · 2020Article
- MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.Cardiovascular diabetology · 2015Article
- Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.BMC endocrine disorders · 2015Article
- Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.Molecular metabolism · 2015Article
- Adiposopathy, "sick fat," Ockham's razor, and resolution of the obesity paradox.Current atherosclerosis reports · 2014Review
- Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.Circulation research · 2012Review
- Lipotoxicity and cardiac dysfunction in mammals and Drosophila.Critical reviews in biochemistry and molecular biology · 2011Review
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα-/- background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.