ArticlePharmacology, biochemistry, and behavior2011
Inactivation of the dorsal raphé nucleus reduces the anxiogenic response of rats running an alley for intravenous cocaine.
Article in Pharmacology, biochemistry, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- Role of α1-GABAJournal of psychopharmacology (Oxford, England) · 2024Article
- Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement.Psychopharmacology · 2021Article
- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Activation of 5-HTBehavioural brain research · 2019Article
- Attenuation of the anxiogenic effects of cocaine by 5-HTPsychopharmacology · 2017Article
- Cocaine Seeking During Initial Abstinence Is Driven by Noradrenergic and Serotonergic Signaling in Hippocampus in a Sex-Dependent Manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Pharmacological modulation of lateral habenular dopamine D2 receptors alters the anxiogenic response to cocaine in a runway model of drug self-administration.Behavioural brain research · 2016Article
- Effects of cocaine history on postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats.Psychopharmacology · 2015Article
- Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.Neuropharmacology · 2015Article
- Prior extended daily access to cocaine elevates the reward threshold in a conditioned place preference test.Addiction biology · 2014Article
- Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats.Psychopharmacology · 2014Article
- Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.Neuropharmacology · 2014Review
- The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats.Pharmacology, biochemistry, and behavior · 2013Article
- Role of GABAA receptors in dorsal raphe nucleus in stress-induced reinstatement of morphine-conditioned place preference in rats.Psychopharmacology · 2013Article
- Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.Neuropharmacology · 2013Article
- Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine.Neuropharmacology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Rats traversing a straight alley once a day for delivery of a single i.v. injection of cocaine develop over trials an ambivalence about entering the goal box. This ambivalence is characterized by the increasing occurrence of "retreat behaviors" where animals leave the start box and run quickly to the goal box, but then stop at the entry point and "retreat" back toward the start box. This unique pattern of retreat behavior has been shown to reflect a form of "approach-avoidance conflict" that stems from the animals' concurrent positive (cocaine reward) and negative (cocaine-induced anxiety) associations with the goal box. Cocaine blocks reuptake of the serotonergic (5-HT) transporter and serotonin has been implicated in the modulation of anxiety. It was therefore of interest to determine whether inactivation of the serotonergic cell bodies residing in the dorsal raphé nucleus (DRN) and projecting to brain areas critical for the modulation of anxiety, would alter the anxiogenic state exhibited by rats running an alley for single daily i.v. injections of 1.0mg/kg cocaine. Reversible inactivation of the DRN was accomplished by intracranial application of a mixed solution of the GABA agonists baclofen and muscimol. While DRN inactivation had no impact on the subjects' motivation to initiate responding (i.e., latencies to leave the start box were unaffected) it reliably reduced the frequency of approach-avoidance retreat behaviors (conflict behavior). These data suggest that inactivation of the dorsal raphé reduces the conflict/anxiety otherwise present in experienced cocaine-seeking animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.