ArticleJournal of periodontal research2011
Periodontal pathogens interfere with quorum-sensing-dependent virulence properties in Streptococcus mutans.
Article in Journal of periodontal research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Phytosphingosine disrupts dual-species oral biofilms and attenuates LPS-induced pro-inflammatory responses in human gingival fibroblasts.Scientific reports · 2026Article
- Quorum sensing in oral multispecies biofilms: from interkingdom communication to therapeutic targeting.Frontiers in microbiology · 2026Review
- Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians.Journal of clinical periodontology · 2024Article
- Acidic Microenvironment-Sensitive Core-Shell Microcubes: The Self-assembled and the Therapeutic Effects for Caries Prevention.European journal of dentistry · 2023Article
- Drugs for the Quorum Sensing Inhibition of Oral Biofilm: New Frontiers and Insights in the Treatment of Periodontitis.Pharmaceutics · 2022Review
- The Oral Microbiome Impacts the Link between Sugar Consumption and Caries: A Preliminary Study.Nutrients · 2022Article
- Efficacy of two mouth rinse sprays in inhibitingThe Saudi dental journal · 2018Article
- Intercellular communications in multispecies oral microbial communities.Frontiers in microbiology · 2014Review
- Exploiting quorum sensing to confuse bacterial pathogens.Microbiology and molecular biology reviews : MMBR · 2013Review
- Bacterial sex in dental plaque.Journal of oral microbiology · 2013Article
- Microbiome and the inflammatory pathway in peri-implant health and disease with an updated review on treatment strategies.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe mechanism by which periodontal pathogens dominate at disease sites is not yet understood. One possibility is that these late colonizers antagonize the quorum-sensing systems of early colonizers and render those early colonizers less resistant to environmental factors. In this study, we utilized Streptococcus mutans, a well-documented oral Streptococcus with many quorum-sensing-dependent properties, as an example of an earlier colonizer antagonized by periodontal pathogens. MATERIAL AND
methodsIn this study, S. mutans NG8 and S. mutans LT11 were used in experiments assessing transformation, and S. mutans BM71 was used in experiments investigating bacteriocin production. The effects of the periodontal pathogens Porphyromonas gingivalis and Treponema denticola on these competence-stimulating peptide-dependent properties were evaluated in mixed-broth assays.
resultsBoth P. gingivalis (either live bacteria or membrane vesicles) and T. denticola antagonized transformation in S. mutans NG8 and LT11. The production of bacteriocin by S. mutans BM71 was also inhibited by P. gingivalis and T. denticola. Boiling of these late colonizers before addition to the broth cultures abolished their ability to inhibit S. mutans transformation and bacteriocin production. P. gingivalis and T. denticola inactivated S. mutans exogenous competence-stimulating peptide, whereas the boiled bacteria did not.
conclusionsThis study demonstrated that periodontal pathogens antagonize S. mutans quorum-sensing properties. This may render S. mutans less virulent and less resistant to environmental antibacterial factors.
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Registered trials
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