ArticleCellular reprogramming2010
Development of a model of sacrocaudal spinal cord injury in cloned Yucatan minipigs for cellular transplantation research.
Article in Cellular reprogramming, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Porcine Models of Spinal Cord Injury.Biomedicines · 2023Review
- Porcine Model of Spinal Cord Injury: A Systematic Review.Neurotrauma reports · 2022Article
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.International journal of molecular sciences · 2020Article
- Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals.Frontiers in neurology · 2019Article
- Therapeutic potential of porcine bronchoalveolar fluid-derived mesenchymal stromal cells in a pig model of LPS-induced ALI.Journal of cellular physiology · 2018Article
- Effect of kidney-reinforcing and marrow-beneficial Chinese medicine on bone metabolism-related factors following spinal cord injury in rats.Experimental and therapeutic medicine · 2016Article
- Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties.Stem cell research & therapy · 2015Article
- Replication of influenza A virus in swine umbilical cord epithelial stem-like cells.Virulence · 2015Article
- Alternating current electric fields of varying frequencies: effects on proliferation and differentiation of porcine neural progenitor cells.Cellular reprogramming · 2013Article
- Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study.Journal of neurotrauma · 2012Article
- Translational spinal cord injury research: preclinical guidelines and challenges.Handbook of clinical neurology · 2012Review
- Cellular treatments for spinal cord injury: the time is right for clinical trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Epithelial cells derived from swine bone marrow express stem cell markers and support influenza virus replication in vitro.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Research into transplantation strategies to treat spinal cord injury (SCI) is frequently performed in rodents, but translation of results to clinical patients can be poor and a large mammalian model of severe SCI is needed. The pig has been considered an optimal model species in which to perform preclinical testing, and the Yucatan minipig can be cloned successfully utilizing somatic cell nuclear transfer (SCNT). However, induction of paralysis in pigs poses significant welfare and nursing challenges. The present study was conducted to determine whether Yucatan SCNT clones could be used to develop an SCI animal model for cellular transplantation research. First, we demonstrated that transection of the sacrocaudal spinal cord in Yucatan SCNT clones produces profound, quantifiable neurological deficits restricted to the tail. We then established that neurospheres could be isolated from brain tissue of green fluorescence protein (GFP) transfected SCNT clones. Finally, we confirmed survival of transplanted GFP-expressing neural stem cells in the SCI lesion and their differentiation into glial and neuronal lineages for up to 4 weeks without immunosuppression. We conclude that this model of sacrocaudal SCI in Yucatan SCNT clones represents a powerful research tool to investigate the effect of cellular transplantation on axonal regeneration and functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.