ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2010
Discovering the unknown: detection of emerging pathogens using a label-free light-scattering system.
Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identifying antibiotic-resistant strains via cell sorting and elastic-light-scatter phenotyping.Applied microbiology and biotechnology · 2024Article
- Bacterial Colony Phenotyping with Hyperspectral Elastic Light Scattering Patterns.Sensors (Basel, Switzerland) · 2023Article
- Rapid Food Authentication Using a Portable Laser-Induced Breakdown Spectroscopy System.Foods (Basel, Switzerland) · 2023Article
- Overcoming Antibiotic Resistance with Novel Paradigms of Antibiotic Selection.Microorganisms · 2022Review
- Development of a Smartphone-Integrated Reflective Scatterometer for Bacterial Identification.Sensors (Basel, Switzerland) · 2022Article
- Petri-plate, bacteria, and laser optical scattering sensor.Frontiers in cellular and infection microbiology · 2022Review
- Advances in Chemical and Biological Methods to Identify Microorganisms-From Past to Present.Microorganisms · 2019Review
- Development of dual reporter imaging system forClinical and experimental vaccine research · 2018Article
- New and developing diagnostic technologies for urinary tract infections.Nature reviews. Urology · 2017Review
- Virulence Gene-Associated Mutant Bacterial Colonies Generate Differentiating Two-Dimensional Laser Scatter Fingerprints.Applied and environmental microbiology · 2016Article
- The effect of a novel low temperature-short time (LTST) process to extend the shelf-life of fluid milk.SpringerPlus · 2016Article
- Article
- Light scattering sensor for direct identification of colonies of Escherichia coli serogroups O26, O45, O103, O111, O121, O145 and O157.PloS one · 2014Article
- Portable bacterial identification system based on elastic light scatter patterns.Journal of biological engineering · 2012Article
- Development of a microbial high-throughput screening instrument based on elastic light scatter patterns.The Review of scientific instruments · 2012Article
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8 authors.
Funding
Abstract
A recently introduced technique for pathogen recognition called BARDOT (BActeria Rapid Detection using Optical scattering Technology) belongs to the broad class of optical sensors and relies on forward-scatter phenotyping (FSP). The specificity of FSP derives from the morphological information that bacterial material encodes on a coherent optical wavefront passing through the colony. The system collects elastically scattered light patterns that, given a constant environment, are unique to each bacterial species and serovar. The notable similarity between FSP technology and spectroscopies is their reliance on statistical machine learning to perform recognition. Currently used methods utilize traditional supervised techniques which assume completeness of training libraries. However, this restrictive assumption is known to be false for most experimental conditions, resulting in unsatisfactory levels of accuracy, poor specificity, and consequently limited overall performance for biodetection and classification tasks. The presented work demonstrates application of the BARDOT system to classify bacteria belonging to the Salmonella class in a nonexhaustive framework, that is, without full knowledge about all the possible classes that can be encountered. Our study uses a Bayesian approach to learning with a nonexhaustive training dataset to allow for the automated detection of unknown bacterial classes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.