ArticleMolecular biology reports2011
Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 34 citations in OpenAlex.
- Bayesian fine-mapping pinpoints candidate genes and pleiotropic loci of production traits from a chicken backcrossing scheme.BMC genomics · 2026Article
- Genetic polymorphisms of the Growth Hormone (GH) gene in Damascus and Black Bengal male goats.Tropical animal health and production · 2025Article
- Phenotype and genotype of Boerka goats raised in Bali.Veterinary world · 2023Article
- Genome Sequence Analysis Reveals Selection Signatures in Endangered Trypanotolerant West African Muturu Cattle.Frontiers in genetics · 2019Article
- Detection of myostatin gene MSTN in some goat breeds (Journal, genetic engineering & biotechnology · 2018Article
- Characterization of the acute heat stress response in gilts: III. Genome-wide association studies of thermotolerance traits in pigs.Journal of animal science · 2018Article
- Investigation of individual heterozygosity correlated to growth traits in Tongshan Black-boned goat.Molecular biology reports · 2013Article
- Molecular cloning, tissue expression and SNP analysis in the goat nerve growth factor gene.Molecular biology reports · 2013Article
- One novel SNP of growth hormone gene and its associations with growth and carcass traits in ducks.Molecular biology reports · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the polymorphisms of growth hormone (GH) gene 5' promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61-0.62, and 0.39-0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82-0.86, and 0.18-0.14, respectively. The SNP loci were in Hardy-Weinberg disequilibrium in both goat breeds (P<0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed.
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