ArticleCellular and molecular neurobiology2011
Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis.
Article in Cellular and molecular neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Does Acupuncture Protect Dopamine Neurons in Parkinson's Disease Rodent Model?: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2019Pooled it
- Sex differences in acupuncture effectiveness in animal models of Parkinson's disease: a systematic review.BMC complementary and alternative medicine · 2016Pooled it
- DNAJB6: A guardian against neurodegeneration.Neural regeneration research · 2026Article
- Multi-omics identification of novel biomarkers and therapeutic targets for Parkinson's disease: from transcriptome to drug interaction.Frontiers in aging neuroscience · 2026Article
- Electro-Acupuncture Inhibits p66Shc-Mediated Oxidative Stress to Facilitate Functional Recovery After Spinal Cord Injury.Journal of molecular neuroscience : MN · 2020Article
- Complementary Medicine Therapies That May Assist With Weight Loss: A Narrative Review.Journal of chiropractic medicine · 2019Review
- Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling.Frontiers in neuroscience · 2019Article
- Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson's Disease.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Early alteration of epigenetic-related transcription in Huntington's disease mouse models.Scientific reports · 2018Article
- Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease.International journal of molecular sciences · 2017Article
- Traditional Chinese medicine for modern treatment of Parkinson's disease.Chinese journal of integrative medicine · 2017Review
- The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss.Oxidative medicine and cellular longevity · 2017Article
- Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model.Journal of neuroinflammation · 2015Article
- Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis.Genetics and molecular biology · 2015Article
- Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease.BMC complementary and alternative medicine · 2014Article
- The neuroprotective role of acupuncture and activation of the BDNF signaling pathway.International journal of molecular sciences · 2014Review
- The holistic effects of acupuncture treatment.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Gene Expression Profiles at Moxibustioned Site (ST36): A Microarray Analysis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Understanding Acupuncture Based on ZHENG Classification from System Perspective.Evidence-based complementary and alternative medicine : eCAM · 2013Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in Parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive. This study investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models after acupuncture at the acupoints GB34 and LR3 using a whole transcript genechip microarray (Affymetrix genechip mouse gene 1.0 ST array). It was confirmed that acupuncture at these acupoints could inhibit the decrease of tyrosine hydroxylase and dopamine transporter in the nigrostriatal region of the MPTP model while acupuncture at the non-acupoints could not counteract this decrease. Genechip gene array analysis (fold change cutoff 1.3 and P < 0.05) showed that 12 of the 69 probes up-regulated in MPTP when compared to the control were down-regulated by acupuncture at the acupoints. Of these 12 probes, 11 probes (nine annotated genes) were exclusively down-regulated by acupuncture only at the acupoints; the Gfral gene was excluded because it was commonly down-regulated by acupuncture at both the acupoints and the non-acupoints. In addition, 28 of the 189 probes down-regulated in MPTP when compared to the control were up-regulated by acupuncture at the acupoints. Of these 28 probes, 19 probes (seven annotated genes) were exclusively up-regulated by acupuncture only at the acupoints while nine probes were commonly up-regulated by acupuncture at both the acupoints and the non-acupoints. The regulation patterns of representative genes in real-time RT-PCR correlated with those of the genes in the microarray. These results suggest that the 30 probes (16 annotated genes), which are affected by MPTP and acupuncture only at the acupoints, are responsible for exerting in the striatal regions the inhibitory effect of acupuncture at the acupoints on MPTP-induced striatal degeneration.
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