ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Daytime baroreflex sensitivity in patients with primary insomnia.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Heart rate variability in patients with insomnia disorder: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review.PloS one · 2017Pooled it
- Comparison of effects of OSA treatment by MAD and by CPAP on cardiac autonomic function during daytime.Sleep & breathing = Schlaf & Atmung · 2016Trial
- Patterns of heart rate reduction during sleep onset in participants with and without insomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Mood Disorders are Correlated with Autonomic Nervous Function in Chronic Insomnia Patients with OSA.Nature and science of sleep · 2023Article
- Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability.Journal of psychiatric research · 2020Article
- Autonomic regulation during mild therapeutic hypothermia in cardiopulmonary resuscitated patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insomnia has been linked to cardiovascular disease and among these especially hypertension and changes in autonomic function. One marker for cardiovascular risk is baroreflex sensitivity (BRS). We investigate daytime BRS in patients with primary insomnia in order to assess cardiovascular risk. Twenty-one patients (18 females/3 males) with primary insomnia according to DSM-IV were recruited. Careful investigations excluded confounding sleep disorders such as sleep-disordered breathing and periodic limb movements. An age-matched control group with 21 healthy subjects (18 females/3 males) underwent the same investigations. To assess BRS, an experimental protocol with paced breathing during daytime was performed. ECG and continuous non-invasive blood pressure were recorded to obtain spontaneous BRS by calculating the α index (BRS-α) and also by transfer function analysis (TF-BRS). There were no differences at daytime between insomnia patients and controls neither in BRS-α (8.1 ms/mmHg, range 5.8-14.7 vs. 9.6 ms/mmHg, range 6.9-15.8) nor in TF-BRS (5.8 ms/mmHg, range 2.4-16.8 vs. 5.4 ms/mmHg, range 2.3-11.4). Also there were no differences in absolute, low or high frequency bands of heart rate or blood pressure variability between the two groups. We could show that primary insomnia may be not associated with daytime parameters of autonomic imbalance (e.g., baroreflex sensitivity) which are known as non-classical risk markers of cardiovascular disease.
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