ArticleJournal of mathematical biology2011
An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium.
Article in Journal of mathematical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- OFrontiers in cellular and infection microbiology · 2025Article
- Long-Distance Effects of H-NS Binding in the Control ofJournal of bacteriology · 2021Article
- Targeted Delivery of the Mitochondrial Target Domain of Noxa to Tumor Tissue via Synthetic Secretion System inFrontiers in bioengineering and biotechnology · 2020Article
- Control of type III protein secretion using a minimal genetic system.Nature communications · 2017Article
- Article
- Epigenetic Control of Salmonella enterica O-Antigen Chain Length: A Tradeoff between Virulence and Bacteriophage Resistance.PLoS genetics · 2015Article
- Salmonella-how a metabolic generalist adopts an intracellular lifestyle during infection.Frontiers in cellular and infection microbiology · 2014Review
- Programmed heterogeneity: epigenetic mechanisms in bacteria.The Journal of biological chemistry · 2013Review
- Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion system.Genetics · 2012Article
- The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1.PLoS pathogens · 2011Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work we consider the regulation system present on the SPI1 pathogenicity island of Salmonella enterica serovar Typhimurium. It is well-known that HilA is the central regulator in the overall scheme of SPI1 regulation and directly binds to virulence operons and activates their expression. The regulation of the expression of HilA is via a complex feed-forward loop involving three transcriptional activators: HilC, HilD and RtsA, and the negative regulator HilE. Our aim is to model this regulation network and study its dynamical behavior. We show that this regulatory system can display a bistable behavior relevant to the biology of Salmonella, and that noise can be a driving force in this system.
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