ArticleNature chemistry2010
Storable, thermally activated, near-infrared chemiluminescent dyes and dye-stained microparticles for optical imaging.
Article in Nature chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
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- A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging.Nature communications · 2025Article
- Half-Curcumin-Based Chemiluminescence Probes and Their Applications in Detecting Quasi-Stable Oxidized Proteins.Angewandte Chemie (International ed. in English) · 2024Article
- Smart molecular probes with controllable photophysical property for smart medicine.Smart molecules : open access · 2024Review
- Persistent luminescent nanophosphors for applications in cancer theranostics, biomedical, imaging and security.Materials today. Bio · 2023Review
- Hetero-Diels-Alder Reaction between Singlet Oxygen and Anthracene Drives Integrative Cage Self-Sorting.Journal of the American Chemical Society · 2023Article
- Tuning the Solid Phase Fluorescence Emission from Long Wavelength Visible to Near-Infrared in Oxazol-5-One Derivatives: Structure-Property Relationship, Theoretical and Experimental Studies.Journal of fluorescence · 2023Article
- Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection.Molecules (Basel, Switzerland) · 2023Article
- Multicomponent synthesis of chromophores - The one-pot approach to functional π-systems.Frontiers in chemistry · 2023Review
- Synthesis and photophysical investigations of pyridine-pyrazolate bound boron(III) diaryl complexes.Scientific reports · 2022Article
- Damming an electronic energy reservoir: ion-regulated electronic energy shuttling in a [2]rotaxane.Chemical science · 2021Article
- Chemically Induced Mismatch of Rings and Stations in [3]Rotaxanes.Journal of the American Chemical Society · 2021Article
- Using the Mechanical Bond to Tune the Performance of a Thermally Activated Delayed Fluorescence Emitter*.Angewandte Chemie (International ed. in English) · 2021Article
- Spin-labelled mechanically interlocked molecules as models for the interpretation of biradical EPR spectra.Chemical science · 2021Article
- Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Novel rhodamine dye with large Stokes shifts by fusing the 1,4-diethylpiperazine moiety and its applications in fast detection of CuRSC advances · 2020Article
- Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo.Nature communications · 2020Article
- Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles.Nanoscale advances · 2020Review
- AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.Journal of the American Chemical Society · 2020Article
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9 authors.
Funding
Abstract
Imaging techniques are a vital part of clinical diagnostics, biomedical research and nanotechnology. Optical molecular imaging makes use of relatively harmless, low-energy light and technically straightforward instrumentation. Self-illuminating, chemiluminescent systems are particularly attractive because they have inherently high signal contrast due to the lack of background emission. Currently, chemiluminescence imaging involves short-lived molecular species that are not stored but are instead generated in situ, and they typically emit visible light, which does not penetrate far through heterogeneous biological media. Here, we describe a new paradigm for optical molecular imaging using squaraine rotaxane endoperoxides, interlocked fluorescent and chemiluminescent dye molecules that have a squaraine chromophore encapsulated inside a macrocycle endoperoxide. Squaraine rotaxane endoperoxides can be stored indefinitely at temperatures below -20 °C, but upon warming to body temperature they undergo a unimolecular chemical reaction and emit near-infrared light that can pass through a living mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.