ReviewNature reviews. Immunology2010
The challenge of immunogenicity in the quest for induced pluripotency.
Review in Nature reviews. Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Altered genome induced immune response of iPSCs.Frontiers in immunology · 2026Article
- Human-Induced Pluripotent Stem Cells in Plastic and Reconstructive Surgery.International journal of molecular sciences · 2024Review
- Current Status of Stem Cell-Derived Therapies for Parkinson's Disease: From Cell Assessment and Imaging Modalities to Clinical Trials.Frontiers in neuroscience · 2020Review
- Major Histocompatibility Complex-Matched Arteries Have Similar Patency to Autologous Arteries in a Mauritian Cynomolgus Macaque Major Histocompatibility Complex-Defined Transplant Model.Journal of the American Heart Association · 2019Article
- HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and their Derivatives.Scientific reports · 2017Article
- Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.Scientific reports · 2017Article
- Modeling psychiatric disorders: from genomic findings to cellular phenotypes.Molecular psychiatry · 2016Review
- Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC.Experimental & molecular medicine · 2016Article
- Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease.Neurogastroenterology and motility · 2016Article
- Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation.Transplantation reviews (Orlando, Fla.) · 2016Review
- Exosomes and Their Therapeutic Potentials of Stem Cells.Stem cells international · 2016Review
- Banking on iPSC--is it doable and is it worthwhile.Stem cell reviews and reports · 2015Article
- Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives.Stem cells and cloning : advances and applications · 2015Review
- Can pluripotent stem cells be used in cell-based therapy?Cellular reprogramming · 2014Review
- The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies.The Journal of biological chemistry · 2014Review
- Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro.Regenerative medicine · 2014Article
- Potential and limitation of HLA-based banking of human pluripotent stem cells for cell therapy.Journal of immunology research · 2014Review
- Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening.Stem cell research & therapy · 2013Review
- The rise of cell therapy trials for stroke: review of published and registered studies.Stem cells and development · 2013Review
- Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.Nature cell biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Few advances have been so widely acclaimed in biology as the seminal demonstration that adult somatic cells can be induced to acquire the phenotype and differentiation potential of embryonic stem cells. The capacity to produce patient-specific stem cells that are truly pluripotent has raised prospects for the treatment of many degenerative diseases through replacement of the affected cell types. In the race to the clinic, however, questions surrounding the potential immunogenicity of such cells have been largely overlooked. Here, I explore the extent of the challenges ahead and suggest that the induction of tolerance to such cells will be crucial to the future success of induced pluripotency.
Indexed as
Identifiers
21107347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.