ArticleMenopause (New York, N.Y.)2011
Mechanisms of cutaneous vasodilation during the postmenopausal hot flash.
Article in Menopause (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of heart rate variability and menopausal vasomotor symptoms.Physiological reports · 2026Pooled it
- Hot flashes and sleep disruption in a randomized trial in menopausal women.American journal of obstetrics and gynecology · 2025Trial
- Continuous transdermal nitroglycerin therapy for menopausal hot flashes: a single-arm, dose-escalation trial.Menopause (New York, N.Y.) · 2016Trial
- Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes.Experimental physiology · 2026Article
- Connecting postmenopausal vasomotor symptoms and blood pressure regulation: a role for the autonomic nervous system?American journal of physiology. Heart and circulatory physiology · 2025Article
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Getting under the skin of the menopausal hot flush: a protocol to examine skin function and structure in symptomatic postmenopausal women.Frontiers in global women's health · 2025Article
- Effects of menopause on temperature regulation.Temperature (Austin, Tex.) · 2025Review
- Vasomotor symptoms of menopause, autonomic dysfunction, and cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2022Review
- Decreased Frequency of Mental Workload-Induced Subjective Hot Flashes Through Gum Massage: An Open-Label, Self-Controlled Crossover Trial.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin.Autonomic neuroscience : basic & clinical · 2021Article
- Oxybutynin vs Placebo for Hot Flashes in Women With or Without Breast Cancer: A Randomized, Double-Blind Clinical Trial (ACCRU SC-1603).JNCI cancer spectrum · 2020Article
- Article
- What's in a name: are menopausal "hot flashes" a symptom of menopause or a manifestation of neurovascular dysregulation?Menopause (New York, N.Y.) · 2018Article
- Autonomic control of body temperature and blood pressure: influences of female sex hormones.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
- Exercise training reduces the acute physiological severity of post-menopausal hot flushes.The Journal of physiology · 2016Article
- The scientific legacy of Stephen Rothman.The Journal of investigative dermatology · 2015Review
- Miniature ambulatory skin conductance monitor and algorithm for investigating hot flash events.Physiological measurement · 2014Article
- Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women.Menopause (New York, N.Y.) · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMenopausal hot flashes can seriously disrupt the lives of symptomatic women. The physiological mechanisms of the hot flash efferent responses, particularly in the cutaneous circulation, are not completely understood. The aim of this study was to examine the mechanisms of increases in skin blood flow during the postmenopausal hot flash in symptomatic women.
methodsHealthy postmenopausal women rested in a temperature-controlled laboratory while responses before and during hot flashes were recorded for three unique protocols. In protocols 1 and 2, women were locally pretreated with an intradermal injection of botulinum toxin A (BTX; blocks the release of neurotransmitters from sympathetic cholinergic nerves) in the forearm (protocol 1) and in the glabellar region (protocol 2). In protocol 3, skin sympathetic nerve activity from the peroneal nerve was recorded, along with skin blood flow and sweating within the region innervated by that neural signal. Skin blood flow was indexed using laser-Doppler flowmetry at the BTX-treated and adjacent untreated control sites. The onset of a hot flash was objectively identified as a transient and pronounced increase in sternal sweat rate.
resultsThe increases in forearm (protocol 1) and glabellar skin (protocol 2) blood flow during hot flashes were attenuated at the BTX sites relative to the adjacent untreated sites (P<0.05 for both protocols). In protocol 3, skin sympathetic nerve activity significantly increased during hot flashes and returned to pre-hot flash levels after the hot flashes.
conclusionsIncreases in skin blood flow during postmenopausal hot flashes are neurally mediated primarily through BTX-sensitive nerves, presumably sympathetic cholinergic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.