Evidence map›Paper›PMID 21106916›Full record

ArticleThe American journal of clinical nutrition2011

Habitual intake of flavonoid subclasses and incident hypertension in adults.

Aedín Cassidy, Éilis J O'Reilly, Colin Kay, Laura Sampson, Mary Franz, J P Forman, Gary Curhan, Eric B Rimm

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06735599 (Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure), which is not on this map. Cited by 199 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 14 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06735599 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure

TypeinterventionalSponsorGeorgia State UniversityRan2024 to 2027Enrolled40ConditionsHypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, FemaleArmsWild Blueberry, Placebo
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 14 syntheses or guidelines pooled it, 499 citations in OpenAlex.

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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aedín CassidySchool of Medicine, University of East Anglia, Norwich, United Kingdom.
Éilis J O'Reilly
Colin Kay
Laura Sampson
Mary Franz
J P Forman
Gary Curhan
Eric B Rimm
University of East Anglia · GB

Funding

RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Novel Risk Factors For HypertensionK08HL079929 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FORMAN, JOHN P · 2006 to 2010
$674k
NHLBI NIH HHS HL079929NHLBI NIH HHS HL34594NHLBI NIH HHS HL35464
6 · The paper itself

Abstract

backgroundDietary flavonoids have beneficial effects on blood pressure in intervention settings, but there is limited information on habitual intake and risk of hypertension in population-based studies.

objectiveWe examined the association between habitual flavonoid intake and incident hypertension in a prospective study in men and women.

designA total of 87,242 women from the Nurses' Health Study (NHS) II, 46,672 women from the NHS I, and 23,043 men from the Health Professionals Follow-Up Study (HPFS) participated in the study. Total flavonoid and subclass intakes were calculated from semiquantitative food-frequency questionnaires collected every 4 y by using an updated and extended US Department of Agriculture database.

resultsDuring 14 y of follow-up, 29,018 cases of hypertension in women and 5629 cases of hypertension in men were reported. In pooled multivariate-adjusted analyses, participants in the highest quintile of anthocyanin intake (predominantly from blueberries and strawberries) had an 8% reduction in risk of hypertension [relative risk (RR): 0.92; 95% CI: 0.86, 0.98; P < 0.03] compared with that for participants in the lowest quintile of anthocyanin intake; the risk reduction was 12% (RR: 0.88; 95% CI: 0.84, 0.93; P < 0.001) in participants ≤60 y of age and 0.96 (0.91, 1.02) in participants >60 y of age (P for age interaction = 0.02). Although intakes of other subclasses were not associated with hypertension, pooled analyses for individual compounds suggested a 5% (95% CI: 0.91, 0.99; P = 0.005) reduction in risk for the highest compared with the lowest quintiles of intake of the flavone apigenin. In participants ≤60 y of age, a 6% (95% CI: 0.88, 0.97; P = 0.002) reduction in risk was observed for the flavan-3-ol catechin when the highest and the lowest quintiles were compared.

conclusionsAnthocyanins and some flavone and flavan-3-ol compounds may contribute to the prevention of hypertension. These vasodilatory properties may result from specific structural similarities (including the B-ring hydroxylation and methyoxylation pattern).

Indexed as

DietPhytotherapyAdultAnthocyaninsApigeninCatechinDiet SurveysFemaleFlavonoidsFollow-Up StudiesFragariaFruitHumansHypertensionIncidenceMaleAnthocyaninsApigeninCatechinFlavonoidsPlant ExtractsVasodilator Agents

Identifiers

PMID21106916
PMCPMC3021426
OpenAlexW2108909778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.