ArticleThe American journal of clinical nutrition2011
Plasma and dietary magnesium and risk of sudden cardiac death in women.
Article in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Circulating magnesium as a potential risk stratification tool for sudden cardiac death: a systematic review.Herzschrittmachertherapie & Elektrophysiologie · 2023Pooled it
- Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies.BMC medicine · 2016Pooled it
- Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.The American journal of clinical nutrition · 2013Pooled it
- Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.PloS one · 2013Pooled it
- The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study.International journal of environmental research and public health · 2021Trial
- Evaluation of Selected Trace Metals' Imbalances in the Whole Blood of Juvenile Idiopathic Arthritis Patients in Comparison with Healthy Subjects.Biological trace element research · 2026Article
- Addressing Magnesium Deficiency Through Crop Biofortification: Plant-Soil-Human Perspective-A Review.Plants (Basel, Switzerland) · 2026Review
- The Importance of Vitamin D and Magnesium in Athletes.Nutrients · 2025Review
- The role of magnesium in cardiac arrest.Frontiers in nutrition · 2024Review
- Serum Magnesium Is Associated with Long-Term Survival of Non-ST-Elevation Myocardial Infarction Patients.Nutrients · 2023Article
- Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease.Journal of the American Heart Association · 2023Article
- Association of dietary magnesium intake and glycohemoglobin with mortality risk in diabetic patients.PloS one · 2022Article
- Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001-2004.Frontiers in nutrition · 2022Article
- Environmental heavy metals and cardiovascular diseases: Status and future direction.Chronic diseases and translational medicine · 2020Review
- Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Article
- Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers.Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies.Nutrients · 2018Review
- The Importance of Magnesium in Clinical Healthcare.Scientifica · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundMagnesium has antiarrhythmic properties in cellular and experimental models; however, its relation to sudden cardiac death (SCD) risk is unclear.
objectiveWe prospectively examined the association between magnesium, as measured in diet and plasma, and risk of SCD.
designThe analysis was conducted within the Nurses' Health Study. The association for magnesium intake was examined prospectively in 88,375 women who were free of disease in 1980. Information on magnesium intake, other nutrients, and lifestyle factors was updated every 2-4 y through questionnaires, and 505 cases of sudden or arrhythmic death were documented over 26 y of follow-up. For plasma magnesium, a nested case-control analysis including 99 SCD cases and 291 controls matched for age, ethnicity, smoking, and presence of cardiovascular disease was performed.
resultsAfter multivariable adjustment for confounders and potential intermediaries, the relative risk of SCD was significantly lower in women in the highest quartile compared with those in the lowest quartile of dietary (relative risk: 0.63; 95% CI: 0.44, 0.91) and plasma (relative risk: 0.23; 95% CI: 0.09, 0.60) magnesium. The linear inverse relation with SCD was strongest for plasma magnesium (P for trend = 0.003), in which each 0.25-mg/dL (1 SD) increment in plasma magnesium was associated with a 41% (95% CI: 15%, 58%) lower risk of SCD.
conclusionsIn this prospective cohort of women, higher plasma concentrations and dietary magnesium intakes were associated with lower risks of SCD. If the observed association is causal, interventions directed at increasing dietary or plasma magnesium might lower the risk of SCD.
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Registered trials
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