ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The role of presynaptic dynamics in processing of natural spike trains in hippocampal synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Power-law adaptation in the presynaptic vesicle cycle.Communications biology · 2025Article
- Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Homeostatic synaptic plasticity rescues neural coding reliability.Nature communications · 2023Article
- Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses.Cell reports · 2022Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Temporal filters in response to presynaptic spike trains: interplay of cellular, synaptic and short-term plasticity time scales.Journal of computational neuroscience · 2022Article
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- Short-Term Synaptic Plasticity: Microscopic Modelling and (Some) Computational Implications.Advances in experimental medicine and biology · 2022Article
- A Slow Short-Term Depression at Purkinje to Deep Cerebellar Nuclear Neuron Synapses Supports Gain-Control and Linear Encoding over Second-Long Time Windows.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A two-compartment model of synaptic computation and plasticity.Molecular brain · 2020Review
- A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration.Neuron · 2018Article
- Doc2-mediated superpriming supports synaptic augmentation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A gradient of frequency-dependent synaptic properties along the longitudinal hippocampal axis.BMC neuroscience · 2017Article
- Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.Molecular psychiatry · 2017Article
- Functional roles of short-term synaptic plasticity with an emphasis on inhibition.Current opinion in neurobiology · 2017Review
- Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits.Journal of neurophysiology · 2016Article
- Modelling the response to low-frequency repetitive nerve stimulation of myasthenia gravis and Lambert-Eaton myasthenic syndrome.Medical & biological engineering & computing · 2016Article
- Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway.Frontiers in neural circuits · 2016Article
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4 authors.
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Abstract
Short-term plasticity (STP) represents a key neuronal mechanism of information processing. In excitatory hippocampal synapses, STP serves as a high-pass filter optimized for the transmission of information-carrying place-field discharges. This STP filter enables synapses to perform a highly nonlinear, switch-like operation permitting the passage and amplification of signals with place-field-like characteristics. Because of the complexity of interactions among STP processes, the synaptic mechanisms underlying this filtering paradigm remain poorly understood. Here, we describe a simple mechanistic model of STP, derived in large part from basic principles of synaptic function, that reproduces this highly nonlinear synaptic behavior. The model, formulated in terms of release probability, considers the interactions between calcium-dependent forms of presynaptic enhancement and their impact on vesicle pool dynamics, which is described using a two-pool model of vesicle recruitment. By considering the interdependency between release probability and various forms of STP, the model attempts to provide a realistic coupling among major presynaptic processes. The model parameters are first determined using synaptic dynamics during constant-frequency stimulation. The model then accurately reproduces all major characteristics of the synaptic filtering paradigm during natural stimulus patterns without free parameters. An elimination approach is then used to identify the contribution of each STP component to synaptic dynamics. Based on this analysis, the model predicts strong calcium dependence of synaptic filtering properties, which is verified experimentally in rat hippocampal slices. This simple model may thus offer a useful framework to further investigate the role of STP in neural computations.
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