ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The absence of eye muscle fatigue indicates that the nervous system compensates for non-motor disturbances of oculomotor function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Fatigue related impairments in oculomotor control are prevented by caffeine.Scientific reports · 2016Trial
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- Altered oculomotor flexibility is linked to high autistic traits.Scientific reports · 2023Article
- A triple distinction of cerebellar function for oculomotor learning and fatigue compensation.PLoS computational biology · 2023Article
- Multidimensional cerebellar computations for flexible kinematic control of movements.Nature communications · 2023Article
- Cerebellar complex spikes multiplex complementary behavioral information.PLoS biology · 2021Article
- Oculomotor Fatigue and Neuropsychological Assessments mirror Multiple Sclerosis Fatigue.Journal of eye movement research · 2020Article
- Corollary Discharge Signals in the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- A loss of a velocity-duration trade-off impairs movement precision in patients with cerebellar degeneration.The European journal of neuroscience · 2018Article
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- Trapezius muscle activity increases during near work activity regardless of accommodation/vergence demand level.European journal of applied physiology · 2015Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Behavioral and Neural Plasticity of Ocular Motor Control: Changes in Performance and fMRI Activity Following Antisaccade Training.Frontiers in human neuroscience · 2015Article
- Short-term saccadic adaptation in the macaque monkey: a binocular mechanism.Journal of neurophysiology · 2013Article
- Smooth pursuit adaptation (SPA) exhibits features useful to compensate changes in the properties of the smooth pursuit eye movement system due to usage.Frontiers in systems neuroscience · 2013Article
- Brain processing of visual information during fast eye movements maintains motor performance.PloS one · 2013Article
- Dynamics of saccade parameters in multiple sclerosis patients with fatigue.Journal of neurology · 2012Article
- Evidence for hyperbolic temporal discounting of reward in control of movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physical properties of our bodies are subject to change (due to fatigue, heavy equipment, injury or aging) as we move around in the surrounding environment. The traditional definition of motor adaptation dictates that a mechanism in our brain needs to compensate for such alterations by appropriately modifying neural motor commands, if the vitally important accuracy of executed movements is to be preserved. In this article we describe how a repetitive eye movement task brings about changes in eye saccade kinematics that compromise accurate motor performance in the absence of a proper compensatory response. Surgical lesions in animals and human patient studies have previously demonstrated that an intact cerebellum is necessary for the compensation to arise and prevent the occurrence of hypometric movements. Here we identified the dynamic properties of the eye plant by recording from abducens motoneurons responsible for the required movement and measured the muscle response to microstimulation of the abducens nucleus in rhesus monkeys. The ensuing results demonstrate that the muscular periphery remains intact during the fatiguing eye movement task, while internal sources of noise (drowsiness, attentional modulation, neuronal fatigue etc.) must be responsible for a diminished oculomotor performance. This finding leads to the important realization that while supervising the accuracy of our movements, the nervous system takes additionally into account and adapts to any disruptive processes within the brain itself, clearly unrelated to the dynamical behavior of muscles or the environment. The existence of this supplementary mechanism forces a reassessment of traditional views of cerebellum-dependent motor adaptation.
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