ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- The Roles of the Numb Protein in Synaptic Development and Plasticity.Developmental neurobiology · 2025Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The environmental toxicant ziram enhances neurotransmitter release and increases neuronal excitability via the EAG family of potassium channels.Neurobiology of disease · 2020Article
- Neurexin and Neuroligins Maintain the Balance of Ghost and Satellite Boutons at theFrontiers in neuroanatomy · 2020Article
- Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.Cell reports · 2019Article
- The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.PLoS genetics · 2019Article
- Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.Oncotarget · 2018Article
- Article
- MAPK3 at the Autism-Linked Human 16p11.2 Locus Influences Precise Synaptic Target Selection atMolecules and cells · 2017Article
- Survival and growth of C57BL/6J mice lacking the BK channel,Physiological reports · 2017Article
- Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.Developmental neurobiology · 2017Article
- Drosophila Homolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions.Experimental neurobiology · 2016Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.Genetics · 2015Article
- The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations.Frontiers in cellular neuroscience · 2015Article
- Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.Development (Cambridge, England) · 2014Article
- unfulfilled interacting genes display branch-specific roles in the development of mushroom body axons in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
- Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.Developmental neurobiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Synapse formation is tightly associated with neuronal excitability. We found striking synaptic overgrowth caused by Drosophila K(+)-channel mutations of the seizure and slowpoke genes, encoding Erg and Ca(2+)-activated large-conductance (BK) channels, respectively. These mutants display two distinct patterns of "satellite" budding from larval motor terminus synaptic boutons. Double-mutant analysis indicates that BK and Erg K(+) channels interact with separate sets of synaptic proteins to affect distinct growth steps. Post-synaptic L-type Ca(2+) channels, Dmca1D, and PSD-95-like scaffold protein, Discs large, are required for satellite budding induced by slowpoke and seizure mutations. Pre-synaptic cacophony Ca(2+) channels and the NCAM-like adhesion molecule, Fasciclin II, take part in a maturation step that is partially arrested by seizure mutations. Importantly, slowpoke and seizure satellites were both suppressed by rutabaga mutations that disrupt Ca(2+)/CaM-dependent adenylyl cyclase, demonstrating a convergence of K(+) channels of different functional categories in regulation of excitability-dependent Ca(2+) influx for triggering cAMP-mediated growth plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.