ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Pyramidal neuron conductance state gates spike-timing-dependent plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- Dynamics of a Mutual Inhibition Circuit between Pyramidal Neurons Compared to Human Perceptual Competition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hebbian plasticity requires compensatory processes on multiple timescales.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Natural Firing Patterns Imply Low Sensitivity of Synaptic Plasticity to Spike Timing Compared with Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Membrane resistance and shunting inhibition: where biophysics meets state-dependent human neurophysiology.The Journal of physiology · 2016Review
- Sloppiness in spontaneously active neuronal networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Shaping synaptic learning by the duration of postsynaptic action potential in a new STDP model.PloS one · 2014Article
- Heterosynaptic plasticity prevents runaway synaptic dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Triphasic spike-timing-dependent plasticity organizes networks to produce robust sequences of neural activity.Frontiers in computational neuroscience · 2012Article
- Synaptic and intrinsic balancing during postnatal development in rat pups exposed to valproic acid in utero.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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3 authors.
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Abstract
Neocortical neurons in vivo process each of their individual inputs in the context of ongoing synaptic background activity, produced by the thousands of presynaptic partners a typical neuron has. Previous work has shown that background activity affects multiple aspects of neuronal and network function. However, its effect on the induction of spike-timing dependent plasticity (STDP) is not clear. Here we report that injections of simulated background conductances (produced by a dynamic-clamp system) into pyramidal cells in rat brain slices selectively reduced the magnitude of timing-dependent synaptic potentiation while leaving the magnitude of timing-dependent synaptic depression unchanged. The conductance-dependent suppression also sharpened the STDP curve, with reliable synaptic potentiation induced only when EPSPs and action potentials (APs) were paired within 8 ms of each other. Dual somatic and dendritic patch recordings suggested that the deficit in synaptic potentiation arose from shunting of dendritic EPSPs and APs. Using a biophysically detailed computational model, we were not only able to replicate the conductance-dependent shunting of dendritic potentials, but show that synaptic background can truncate calcium dynamics within dendritic spines in a way that affects potentiation more strongly than depression. This conductance-dependent regulation of synaptic plasticity may constitute a novel homeostatic mechanism that can prevent the runaway synaptic potentiation to which Hebbian networks are vulnerable.
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