ArticleJournal of virology2011
Gaining replicability in a nonhost compromises the silencing suppression activity of Tobacco mild green mosaic virus in a host.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- To Be Seen or Not to Be Seen: Latent Infection by Tobamoviruses.Plants (Basel, Switzerland) · 2022Review
- First genome analysis and molecular characterization of Chickpea chlorotic dwarf virus Egyptian isolate infecting squash.Virusdisease · 2015Article
- Functional characterization of the mutations in Pepper mild mottle virus overcoming tomato tm-1-mediated resistance.Molecular plant pathology · 2014Article
- The hypervariable amino-terminus of P1 protease modulates potyviral replication and host defense responses.PLoS pathogens · 2014Article
- Fitness penalty in susceptible host is associated with virulence of Soybean mosaic virus on Rsv1-genotype soybean: a consequence of perturbation of HC-Pro and not P3.Molecular plant pathology · 2013Article
- Tsw gene-based resistance is triggered by a functional RNA silencing suppressor protein of the Tomato spotted wilt virus.Molecular plant pathology · 2013Article
- Coevolution and hierarchical interactions of Tomato mosaic virus and the resistance gene Tm-1.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural isolates of Tobacco mild green mosaic virus (TMGMV) fail to infect tomato because the tomato tm-1 protein binds to the replication proteins of TMGMV and prevents RNA replication. Previously, we isolated a TMGMV mutant that overcomes tm-1-mediated resistance and multiplies in tomato plants. Here, we show that the causal mutations in the replication protein gene that abolish the interaction with tm-1 reduce its ability to suppress RNA silencing in host plant Nicotiana benthamiana. The results suggest that the multifunctionality of the replication proteins is an evolutionary constraint of tobamoviruses that restricts their host ranges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.