ArticleAmerican journal of physiology. Cell physiology2011
Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells.
Article in American journal of physiology. Cell physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance.American journal of physiology. Heart and circulatory physiology · 2026Trial
- Pharmaceutical agents targeting KThe journal of physiological sciences : JPS · 2026Article
- Article
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- Effect of kokumi taste-active γ-glutamyl peptides on amiloride-sensitive epithelial NaBiochemistry and biophysics reports · 2023Article
- Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature.International journal of molecular sciences · 2021Review
- Recent Advances in Neural Circuits for Taste Perception in Hunger.Frontiers in neural circuits · 2021Review
- Association of Salivary Content Alteration and Early Ageusia Symptoms in COVID-19 Infections: A Systematic Review.European journal of dentistry · 2020Article
- Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?Diabetes & metabolism journal · 2020Review
- Taste Receptor Cells in Mice Express Receptors for the Hormone Adiponectin.Chemical senses · 2019Article
- Article
- Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells.Journal of the American Society of Hypertension : JASH · 2018Article
- Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.Journal of the American Heart Association · 2017Review
- Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats.PloS one · 2017Article
- Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines.European biophysics journal : EBJ · 2016Article
- A High-Throughput Automated Microfluidic Platform for Calcium Imaging of Taste Sensing.Molecules (Basel, Switzerland) · 2016Article
- Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.Chemical senses · 2015Article
- Molecular mechanisms of taste recognition: considerations about the role of saliva.International journal of molecular sciences · 2015Review
- Taste perception, associated hormonal modulation, and nutrient intake.Nutrition reviews · 2015Review
- Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Diabetes is a profound disease that results in a severe lack of regulation of systemic salt and water balance. From our earlier work on the endocrine regulation of salt taste at the level of the epithelial sodium channel (ENaC), we have begun to investigate the ability of insulin to alter ENaC function with patch-clamp recording on isolated mouse taste receptor cells (TRCs). In fungiform and vallate TRCs that exhibit functional ENaC currents (e.g., amiloride-sensitive Na(+) influx), insulin (5-20 nM) caused a significant increase in Na(+) influx at -80 mV (EC(50) = 7.53 nM). The insulin-enhanced currents were inhibited by amiloride (30 μM). Similarly, in ratiometric Na(+) imaging using SBFI, insulin treatment (20 nM) enhanced Na(+) movement in TRCs, consistent with its action in electrophysiological assays. The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 μM) abolished insulin-induced changes in ENaC. To test the role of insulin in the regulation of salt taste, we have characterized behavioral responses to NaCl using a mouse model of acute hyperinsulinemia. Insulin-treated mice show significant avoidance of NaCl at lower concentrations than the control group. Interestingly, these differences between groups were abolished when amiloride (100 μM) was added into NaCl solutions, suggesting that insulin was regulating ENaC. Our results are consistent with a role for insulin in maintaining functional expression of ENaC in mouse TRCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.