ArticleProceedings. Biological sciences2011
Evolution of adaptive phenotypic variation patterns by direct selection for evolvability.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Pooled it
- A global meta-analysis reveals higher variation in breeding phenology in urban birds than in their non-urban neighbours.Ecology letters · 2022Pooled it
- Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP).Journal of human genetics · 2022Trial
- Wanted: A population genetic theory of biological noise regulation.PLoS genetics · 2026Article
- The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Understanding developmental system drift.Development (Cambridge, England) · 2024Review
- Vertically inherited microbiota and environment modifying behaviours conceal genetic variation in dung beetle life history.Proceedings. Biological sciences · 2024Article
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- Developmental bias as a cause and consequence of adaptive radiation and divergence.Frontiers in cell and developmental biology · 2024Review
- The evolution of genetic covariance and modularity as a result of multigenerational environmental fluctuation.Evolution letters · 2023Article
- Diversification of the ruminant skull along an evolutionary line of least resistance.Science advances · 2023Article
- Condition dependence of phenotypic integration and the evolvability of genitalic traits in a neriid fly.Biology letters · 2020Article
- How to fit in: The learning principles of cell differentiation.PLoS computational biology · 2020Article
- Effectiveness of Genomic Selection by Response to Selection for Winter Wheat Variety Improvement.The plant genome · 2019Article
- Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.Alzheimer's research & therapy · 2018Article
- Article
- Review
- Genetic mapping of molar size relations identifies inhibitory locus for third molars in mice.Heredity · 2018Article
- Evolutionary dynamics of the leaf phenological cycle in an oak metapopulation along an elevation gradient.Journal of evolutionary biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A basic assumption of the Darwinian theory of evolution is that heritable variation arises randomly. In this context, randomness means that mutations arise irrespective of the current adaptive needs imposed by the environment. It is broadly accepted, however, that phenotypic variation is not uniformly distributed among phenotypic traits, some traits tend to covary, while others vary independently, and again others barely vary at all. Furthermore, it is well established that patterns of trait variation differ among species. Specifically, traits that serve different functions tend to be less correlated, as for instance forelimbs and hind limbs in bats and humans, compared with the limbs of quadrupedal mammals. Recently, a novel class of genetic elements has been identified in mouse gene-mapping studies that modify correlations among quantitative traits. These loci are called relationship loci, or relationship Quantitative Trait Loci (rQTL), and affect trait correlations by changing the expression of the existing genetic variation through gene interaction. Here, we present a population genetic model of how natural selection acts on rQTL. Contrary to the usual neo-Darwinian theory, in this model, new heritable phenotypic variation is produced along the selected dimension in response to directional selection. The results predict that selection on rQTL leads to higher correlations among traits that are simultaneously under directional selection. On the other hand, traits that are not simultaneously under directional selection are predicted to evolve lower correlations. These results and the previously demonstrated existence of rQTL variation, show a mechanism by which natural selection can directly enhance the evolvability of complex organisms along lines of adaptive change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.