ArticleTrends in genetics : TIG2011
DNA double-strand break repair and the evolution of intron density.
Article in Trends in genetics : TIG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 82 citations in OpenAlex.
- Genome-wide identification and expression profiling of the CoVQ gene family in Camellia Oleifera.BMC plant biology · 2026Article
- The mutation landscape ofbioRxiv : the preprint server for biology · 2025Article
- Phylogenetic Analysis of 590 Species Reveals Distinct Evolutionary Patterns of Intron-Exon Gene Structures Across Eukaryotic Lineages.Molecular biology and evolution · 2024Article
- Review
- New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement.International journal of molecular sciences · 2023Review
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- Analysis of Fungal Genomes Reveals Commonalities of Intron Gain or Loss and Functions in Intron-Poor Species.Molecular biology and evolution · 2021Article
- Comparative genomics of Chlamydomonas.The Plant cell · 2021Article
- DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids.Frontiers in cell and developmental biology · 2021Review
- The C- and G-value paradox with polyploidy, repeatomes, introns, phenomes and cell economy.Genes & genomics · 2020Review
- Complex Evolution of Insect Insulin Receptors and Homologous Decoy Receptors, and Functional Significance of Their Multiplicity.Molecular biology and evolution · 2020Article
- Expansion and Functional Diversification ofInternational journal of molecular sciences · 2019Article
- Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.PLoS biology · 2019Article
- Parallel loss of introns in the ABCB1 gene in angiosperms.BMC evolutionary biology · 2017Article
- Origin and Spread of Spliceosomal Introns: Insights from the Fungal Clade Zymoseptoria.Genome biology and evolution · 2017Article
- Emergence and loss of spliceosomal twin introns.Fungal biology and biotechnology · 2017Article
- Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium.BMC evolutionary biology · 2015Article
- Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans.Nuclear medicine and biology · 2015Article
- Intron evolution in Neurospora: the role of mutational bias and selection.Genome research · 2015Article
- Intron evolution in Saccharomycetaceae.Genome biology and evolution · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The density of introns is both an important feature of genome architecture and a highly variable trait across eukaryotes. This heterogeneity has posed an evolutionary puzzle for the last 30 years. Recent evidence is consistent with novel introns being the outcome of the error-prone repair of DNA double-stranded breaks (DSBs) via non-homologous end joining (NHEJ). Here we suggest that deletion of pre-existing introns could occur via the same pathway. We propose a novel framework in which species-specific differences in the activity of NHEJ and homologous recombination (HR) during the repair of DSBs underlie changes in intron density.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.