ArticleBMC bioinformatics2010
Analysis and verification of the HMGB1 signaling pathway.
Article in BMC bioinformatics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- LncRNA FTX accelerates the progression of hepatocellular carcinoma by FTX/miR-374a-3p/HMGB1 pathway.International journal of medical sciences · 2025Article
- Formal verification confirms the role of p53 protein in cell fate decision mechanism.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Role of high-mobility group box 1 in cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks.Journal of inflammation research · 2022Article
- Article
- Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy.Cancer discovery · 2021Review
- An Integrative Analysis of Time-varying Regulatory Networks From High-dimensional Data.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2018Article
- Computational Modeling, Formal Analysis, and Tools for Systems Biology.PLoS computational biology · 2016Review
- Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia.PloS one · 2016Article
- Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases.Diagnostics (Basel, Switzerland) · 2015Review
- HMGB1 bound to cisplatin-DNA adducts undergoes extensive acetylation and phosphorylationChemical science · 2015Article
- Emerging roles for HMGB1 protein in immunity, inflammation, and cancer.ImmunoTargets and therapy · 2015Review
- A novel procedure for statistical inference and verification of gene regulatory subnetwork.BMC bioinformatics · 2015Article
- Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression.Hepatitis monthly · 2014Article
- Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.Marine drugs · 2014Review
- Computational analysis of the roles of ER-Golgi network in the cell cycle.BMC systems biology · 2014Article
- Systems biology of cancer: a challenging expedition for clinical and quantitative biologists.Frontiers in bioengineering and biotechnology · 2014Article
- HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.PloS one · 2014Article
- Analysis of intercellular signal transduction in the tumor microenvironment.BMC systems biology · 2013Article
- Proteomic analysis of apoptotic and oncotic pancreatic acinar AR42J cells treated with caerulein.Molecular and cellular biochemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic.
resultsWe have developed a rule-based model of crosstalk between the HMGB1 signaling pathway and other key cancer signaling pathways. The model has been simulated using both ordinary differential equations (ODEs) and discrete stochastic simulation. We have applied an automated verification technique, Statistical Model Checking, to validate interesting temporal properties of our model.
conclusionsOur simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. Discrete, stochastic simulations show that p53 and MDM2 oscillations continue even after 10 hours, as observed by experiments. This property is not exhibited by the deterministic ODE simulation, for the chosen parameters. Moreover, the models also predict that mutations of RAS, ARF and P21 in the context of HMGB1 signaling can influence the cancer cell's fate - apoptosis or survival - through the crosstalk of different pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.