ArticleCardiovascular diabetology2010
Hemodynamic and autonomic response to acute hemorrhage in streptozotocin-induced diabetic rats.
Article in Cardiovascular diabetology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- The Effects of Acute Blood Loss for Diagnostic Bloodwork and Fluid Replacement in Clinically Ill Mice.Comparative medicine · 2015Article
- β2-adrenergic regulation of stress hyperglycemia following hemorrhage in the obese Zucker rat.Physiological reports · 2014Article
- Impaired blood pressure compensation following hemorrhage in conscious obese Zucker rats.Life sciences · 2013Article
- Signaling prodromes of sudden cardiac death.Bosnian journal of basic medical sciences · 2013Article
- Article
- The effects of green tea consumption on cardiometabolic alterations induced by experimental diabetes.Experimental diabetes research · 2012Article
- Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma.American journal of physiology. Heart and circulatory physiology · 2012Article
- Renal denervation in an animal model of diabetes and hypertension: impact on the autonomic nervous system and nephropathy.Cardiovascular diabetology · 2011Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe various autonomic control systems lead to characteristic changes in heart rate (HR) and blood pressure (BP) during acute hemorrhage. However, cardiovascular autonomic neuropathy due to diabetes mellitus may interfere with the normal compensation for hemorrhage. MATERIALS AND
methodsA controlled graded bleeding (6 - 36% loss of estimated total blood volume: ETBV) was performed in streptozotocin-induced diabetic rats (STZ rats) under a conscious state. Hemodynamic and autonomic responses to acute hemorrhage were examined using analysis of BP-HR variability. The effects of dextran treatment after hemorrhage were also examined.
resultsA significant reduction in mean arterial pressure began at 12% ETBV loss in STZ rats and 18% in the control rats, respectively. When blood loss reached 18% of TEBV, the decrease in HR was prominent in STD rats due to the activation of a parasympathetic drive, as indicated by the increase in high frequency (HF; 0.75~3.0 Hz) power in HR variability, while in the control rats this response was not observed. The administration of dextran prevented the activation of the parasympathetic drive in STZ rats during hemorrhaging. In the control rats, the dextran treatment sustained the initial increase in HR with reduced HF power in HR variability.
conclusionSTZ rats showed different hemodynamic and autonomic responses to acute hemorrhage from the control rats. STZ rats were prone to develop bradycardiac hypotension characterized by marked parasympathetic activation during hemorrhaging. This finding suggests enhancement of the Bezold-Jarisch reflex in STZ rats. Dextran treatment to maintain a normovolemic hemorrhage state inhibits this reflex.
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