ArticleGenome biology2010
Genetic diversity in India and the inference of Eurasian population expansion.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MTHFR gene polymorphism in acute lymphoblastic leukemia among North Indian children: a case-control study and meta-analysis updated from 2011.Journal of human genetics · 2014Pooled it
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- Access and barriers to genomic classifiers for breast cancer and prostate cancer in India.International journal of cancer · 2024Review
- Development of a decentralized cohort for studying post-acute sequelae of COVID-19 in India in the Data4life Study.Communications medicine · 2023Article
- Prevalence of Traditional Risk Factors in First-Degree Relatives of Patients With Established Cardiovascular Disease.Cureus · 2023Article
- Disease characteristics and clinical outcomes of adults and children with anti-MDA-5 antibody-associated myositis: a prospective observational bicentric study.Rheumatology international · 2022Observational
- Extending precision medicine tools to populations at high risk of type 2 diabetes.PLoS medicine · 2022Article
- AnNAR genomics and bioinformatics · 2022Article
- COVID-19: Impact on linguistic and genetic isolates of India.Genes and immunity · 2022Article
- Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2022Article
- Article
- A data set of variants derived from 1455 clinical and research exomes is efficient in variant prioritization for early-onset monogenic disorders in Indians.Human mutation · 2021Article
- Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations.PloS one · 2020Article
- The genetic legacy of continental scale admixture in Indian Austroasiatic speakers.Scientific reports · 2019Article
- Activation of Epithelial-Mesenchymal Transition and Altered β-Catenin Signaling in a Novel Indian Colorectal Carcinoma Cell Line.Frontiers in oncology · 2019Article
- The Genetic Ancestry of Modern Indus Valley Populations from Northwest India.American journal of human genetics · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundGenetic studies of populations from the Indian subcontinent are of great interest because of India's large population size, complex demographic history, and unique social structure. Despite recent large-scale efforts in discovering human genetic variation, India's vast reservoir of genetic diversity remains largely unexplored.
resultsTo analyze an unbiased sample of genetic diversity in India and to investigate human migration history in Eurasia, we resequenced one 100-kb ENCODE region in 92 samples collected from three castes and one tribal group from the state of Andhra Pradesh in south India. Analyses of the four Indian populations, along with eight HapMap populations (692 samples), showed that 30% of all SNPs in the south Indian populations are not seen in HapMap populations. Several Indian populations, such as the Yadava, Mala/Madiga, and Irula, have nucleotide diversity levels as high as those of HapMap African populations. Using unbiased allele-frequency spectra, we investigated the expansion of human populations into Eurasia. The divergence time estimates among the major population groups suggest that Eurasian populations in this study diverged from Africans during the same time frame (approximately 90 to 110 thousand years ago). The divergence among different Eurasian populations occurred more than 40,000 years after their divergence with Africans.
conclusionsOur results show that Indian populations harbor large amounts of genetic variation that have not been surveyed adequately by public SNP discovery efforts. Our data also support a delayed expansion hypothesis in which an ancestral Eurasian founding population remained isolated long after the out-of-Africa diaspora, before expanding throughout Eurasia.
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